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Fig. 3 | Breast Cancer Research

Fig. 3

From: TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells

Fig. 3

GO enrichment and KEGG pathway analysis of the FGFR1 signaling-regulated genes in DCIS-iFGFR1 cells. a GO analysis of the 946 AP20187-changed genes in DCIS-iFGFR1 cells identified 191 terms with significant gene enrichment based on biological processes (p < 0.05). The top 25 significantly enriched terms are shown here. b GO analysis of the 946 AP20187-regulated genes identified 38 terms with significant gene enrichment based on molecular functions (p < 0.05). The top 25 significantly enriched terms are listed. c Top 32 pathways identified by the KEGG pathway analysis of the 946 AP20187-changed genes in DCIS-iFGFR1 cells. p < 0.05 was used as a threshold to select significant GO terms and KEGG pathways. The -log(p value) is the negative log10 of the p value. act. activity, bind. binding, GNE guanyl-nuclotide exchange, (+) Reg. positive regulation, (−) Reg. negative regulation, SCs stem cells, Seq. sequence, trans. Transcription, TF transcription factor,

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Breast Cancer Research

ISSN: 1465-542X

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