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Table 1 Overview of the clinical and histological characteristics of the primary and secondary tumours

From: Clonal relatedness in tumour pairs of breast cancer patients

      Primary tumour Secondary tumour   
Patient Laterality Synchronicity Group Time interval (days) Histology ER HER2 Molecular subtype Histology ER HER2 Molecular subtype Discordance Clinical classification
BM1 bilateral metachronous BM 346 Invasive carcinoma NST pos neg ND ND pos neg ND   concordant
BM2 bilateral metachronous BM 1694 Invasive carcinoma NST pos neg Luminal B Invasive lobular carcinoma pos neg ND Histology discordant
BM3 bilateral metachronous BM 1652 ND pos neg ND Invasive carcinoma NST pos neg ND   concordant
BM4 bilateral metachronous BM 581 Invasive carcinoma NST neg neg Basal-like Invasive carcinoma NST neg neg ND   concordant
BM5 bilateral metachronous BM 1954 Invasive carcinoma NST pos neg ND Invasive lobular carcinoma pos neg ND Histology discordant
BM6 bilateral metachronous BM 1417 Invasive lobular carcinoma pos neg ND Invasive carcinoma NST neg neg HER2/ER- Histology; ER discordant
BM7 bilateral metachronous BM 456 Invasive carcinoma NST pos pos ND Invasive carcinoma NST neg pos ND ER discordant
BM8 bilateral metachronous BM 1152 Invasive lobular carcinoma pos neg ND Invasive lobular carcinoma pos neg ND   concordant
BM9 bilateral metachronous BM 972 Invasive carcinoma NST neg neg ND Invasive carcinoma NST neg neg ND   concordant
BS1 bilateral synchronous BS 0 Invasive carcinoma NST pos neg ND Invasive carcinoma NST pos neg Luminal B   concordant
BS2 bilateral synchronous BS 0 Invasive lobular carcinoma pos neg ND Invasive carcinoma NST pos neg Luminal B Histology discordant
BS3 bilateral synchronous BS 14 Invasive carcinoma NST pos neg ND Invasive carcinoma NST pos neg ND   concordant
BS4 bilateral synchronous BS 0 ND pos neg ND ND pos neg ND   concordant
BS5 bilateral synchronous BS 6 Invasive carcinoma NST pos neg ND Invasive carcinoma NST ND neg ND   concordant
BS6 bilateral synchronous BS 0 ND neg neg ND ND neg neg ND   concordant
BS7 bilateral synchronous BS 0 Invasive carcinoma NOS pos neg Luminal B Invasive lobular carcinoma neg neg ND Histology; ER discordant
BS8 bilateral synchronous BS 0 Invasive carcinoma NST pos neg ND Invasive carcinoma NST pos neg ND   concordant
IM1 ipsilateral metachronous IM 1855 ND pos neg ND ND pos neg Luminal B   concordant
IM2 ipsilateral metachronous IM 448 ND neg neg ND ND neg neg ND   concordant
IM3 ipsilateral metachronous IM 1944 Invasive carcinoma NST pos pos Luminal B ND pos pos Luminal B   concordant
IM4 ipsilateral metachronous IM 567 Invasive carcinoma NST pos neg Luminal B ND pos neg HER2/ER- Subtype discordant
IM5 ipsilateral metachronous IM 712 Invasive carcinoma NST neg neg Basal-like ND neg neg ND   concordant
IM6 ipsilateral metachronous IM 664 ND pos neg ND ND pos neg ND   concordant
IM7 ipsilateral metachronous IM 2454 ND pos neg ND ND pos neg ND   concordant
IM8 ipsilateral metachronous IM 563 Invasive carcinoma NST pos neg ND Invasive lobular carcinoma pos neg Luminal B Histology discordant
IM9 ipsilateral metachronous IM 2142 Invasive carcinoma NOS ND neg Luminal B Invasive carcinoma NOS pos neg Luminal B   concordant
IS1 ipsilateral synchronous IS 0 Invasive carcinoma NST neg neg Basal-like Invasive carcinoma NST neg pos Luminal B HER2; subtype discordant
IS2 ipsilateral synchronous IS 0 Invasive carcinoma NST pos neg ND ND pos neg Luminal B   concordant
IS3 ipsilateral synchronous IS 0 ND neg neg Basal-like ND neg pos Basal-like HER2 discordant
IS4 ipsilateral synchronous IS 50 ND neg neg ND ND pos neg Luminal B ER discordant
IS5 ipsilateral synchronous IS 0 Invasive carcinoma NST pos neg Luminal B Invasive carcinoma NST pos neg Luminal B   concordant
IS6 ipsilateral synchronous IS 0 Invasive carcinoma NST pos neg ND ND pos neg ND   concordant
IS7 ipsilateral synchronous IS 0 Invasive carcinoma NOS pos neg ND ND pos neg ND   concordant
IS8 ipsilateral synchronous IS 0 Invasive carcinoma NST pos neg Luminal B ND pos neg ND   concordant
IS9 ipsilateral synchronous IS 0 ND neg pos Basal-like ND neg neg ND HER2 discordant
IS10 ipsilateral synchronous IS 0 Invasive carcinoma NST pos neg Luminal B ND pos neg Luminal B   concordant
IS11 ipsilateral synchronous IS 0 Invasive carcinoma NOS neg pos HER2/ER- ND neg pos HER2/ER-   concordant
  1. ER oestrogen receptor status, HER2 human epidermal growth factor receptor 2 status, ND not determined, NOS not otherwise specified, NST no special type