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Table 5 Cancer yield, FPR and FPB results for mammography (A), MRI (B), and the combination (C)

From: The added value of mammography in different age-groups of women with and without BRCA mutation screened with breast MRI

Age category Risk category Cancer yielda (95% CI) FPRa (95% CI) FPBa (95% CI)
A. Mammography
 <  40 years Overall 6.54 (3.73–11.46) 36.06 (27.57–47.03) 19.48 (13.73–27.58)
BRCA 7.17 (3.61–14.18) 26.96 (18.07–40.03) 15.52 (9.03–26.57)
No BRCA 5.61 (2.10–14.89) 49.62 (34.62–70.64) 24.94 (15.94–38.83)
 40–50 years Overall 6.35 (3.71–10.83) 40.44 (31.53–51.72) 24.23 (17.66–33.16)
BRCA 6.78 (2.85–16.02) 18.90 (11.26–31.56) 12.21 (6.37–23.30)
No BRCA 6.11 (3.08–12.06) 52.66 (39.80–69.38) 30.56 (21.36–43.55)
 50–60 years Overall 13.57 (9.21–19.94) 33.28 (24.94–44.29) 18.38 (12.60–26.75)
BRCA 26.10 (15.93–42.47) 10.56 (4.75–23.31) 8.85 (3.67–21.15)
No BRCA 7.89 (4.26–14.58) 43.06 (31.68–58.27) 22.16 (14.61–33.47)
 ≥ 60 years Overall 17.72 (10.81–28.93) 25.82 (16.76–39.58) 10.88 (5.64–20.90)
BRCA 21.48 (7.99–56.49) 10.69 (2.64–42.22) 0.00 (N/A)
No BRCA 16.90 (9.54–29.77) 30.38 (19.27–47.57) 14.14 (7.31–27.15)
 Overall Overall 9.95 (7.80–12.69) 36.42 (31.42–42.19) 20.05 (16.49–24.37)
BRCA 12.44 (8.75–17.65) 20.65 (15.32–27.77) 12.56 (8.50–18.51)
No BRCA 8.33 (5.95–11.65) 47.08 (39.74–55.71) 24.95 (19.91–31.24)
B. MRI
 <  40 years Overall 13.09 (8.80–19.44) 87.25 (74.68–101.71) 62.30 (51.89–74.63)
BRCA 14.31 (8.81–23.16) 75.49 (60.59–93.70) 56.72 (44.03–72.79)
No BRCA 11.22 (5.61–22.31) 104.96 (84.38–129.84) 70.70 (54.44–91.35)
 40–50 years Overall 14.06 (9.83–20.07) 70.45 (59.44–83.31) 55.95 (46.39–67.33)
BRCA 18.86 (11.26–31.42) 47.03 (34.06–64.61) 34.73 (23.93–50.15)
No BRCA 11.37 (6.91–18.66) 82.49 (67.63–100.27) 67.55 (54.44–83.53)
 50–60 years Overall 19.56 (14.16–26.96) 41.64 (32.53–53.16) 29.88 (22.29–39.94)
BRCA 40.37 (27.00–59.96) 44.36 (29.42–66.36) 30.66 (18.27–51.02)
No BRCA 10.25 (5.97–17.55) 40.08 (29.42–54.38) 29.41 (20.59–41.84)
 ≥ 60 years Overall 23.56 (15.39–35.93) 29.04 (19.45–43.15) 20.49 (12.72–32.85)
BRCA 21.48 (7.99–56.49) 10.85 (2.66–43.12) 10.85 (2.66–43.12)
No BRCA 24.40 (15.23–38.87) 34.37 (22.63–51.89) 23.31 (14.04–38.45)
 Overall Overall 16.64 (13.81–20.04) 62.52 (56.37–69.29) 46.27 (41.11–52.06)
BRCA 22.08 (17.03–28.60) 56.98 (48.07–67.42) 41.81 (34.35–50.80)
No BRCA 13.10 (10.02–17.10) 66.13 (58.03–75.27) 49.21 (42.42–57.03)
C. Combination
 <  40 years Overall 13.56 (9.24–20.10) 99.78 (86.35–115.04) 65.68 (54.96–78.31)
BRCA 14.31 (8.81–23.16) 85.01 (69.45–103.66) 60.34 (47.29–76.70)
No BRCA 12.65 (6.58–24.21) 121.64 (99.00–148.59) 73.85 (56.96–95.26)
 40–50 years Overall 15.02 (10.64–21.17) 89.74 (77.29–103.98) 63.26 (53.13–75.18)
BRCA 18.86 (11.26–31.42) 57.42 (42.61–76.97) 42.39 (29.86–59.85)
No BRCA 12.89 (8.10–20.48) 107.19 (90.27–126.84) 74.68 (61.11–90.97)
 50–60 years Overall 23.82 (17.82–31.76) 60.11 (48.79–73.85) 36.58 (28.05–47.59)
BRCA 45.29 (31.14–65.43) 47.62 (32.20–69.90) 33.91 (20.91–54.54)
No BRCA 14.16 (8.97–22.29) 65.53 (51.26–83.42) 37.51 (27.28–51.37)
 ≥ 60 years Overall 26.49 (17.31–40.36) 46.86 (34.05–64.17) 24.16 (15.57–37.33)
BRCA 21.48 (7.99–56.49) 22.05 (8.12–58.46) 10.85 (2.66–43.12)
No BRCA 27.87 (17.39–44.38) 54.21 (38.71–75.43) 28.06 (17.67–44.30)
 Overall Overall 18.68 (15.65–22.27) 79.65 (72.70–87.21) 51.73 (46.28–57.78)
BRCA 23.17 (18.00–29.79) 65.59 (56.09–76.55) 46.14 (38.31–55.47)
No BRCA 15.74 (12.28–20.15) 89.14 (79.65–99.64) 55.39 (48.20–63.57)
  1. aGeneral estimating equations were used to calculate performance measures, correcting for multiple screening rounds within the same patient. All measurements are per 1000 examinations
  2. MRI magnetic resonance imaging, N/A no cancers, recalls, or biopsies were found in this category and no 95% CI of this measure could be calculated, 95% CI Wald 95% confidence intervals