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Fig. 2 | Breast Cancer Research

Fig. 2

From: Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth

Fig. 2

Tricho-rhino-phalangeal syndrome 1 (TRPS1) transcription factor stabilizes histone deacetylase 2 (HDAC2) through ubiquitin-dependent proteasomal degradation (UDPD). MCF7 (a), T47D (b), and BT474 (c) show decreased HDAC2 protein levels upon MG132 treatment in cells with silencing of TRPS1. d Ectopic overexpression of TRPS1 reduced HDAC2 ubiquitination level in HEK293T. DMSO, dimethyl sulfoxide; siRNA, small interfering RNA

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Breast Cancer Research

ISSN: 1465-542X

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