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Fig. 1 | Breast Cancer Research

Fig. 1

From: Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth

Fig. 1

Tricho-rhino-phalangeal syndrome 1 (TRPS1) transcription factor negatively regulates histone deacetylase 2 (HDAC2) protein level by stabilizing the HDAC2 protein. MCF7 (a), T47D (b), and BT474 (c) exhibit decreased HDAC2 protein levels upon silencing TRPS1. MCF7 (d), T47D (e), and BT474 (f) exhibit insignificant alterations in HDAC2 messenger RNA levels upon silencing TRPS1. MCF7 (g), T47D (h), and BT474 (i) show decreased HDAC2 protein stability upon silencing TRPS1. The t test was used for statistical quantification: *p < 0.05, **p < 0.01, ***p < 0.001, respectively. siRNA, small interfering RNA; CHX, cycloheximide

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Breast Cancer Research

ISSN: 1465-542X

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