Fig. 2
Whole genome CNV profiles of chemoradiation-naïve TNBCs with high levels of PD-L1 expression on tumor cell surfaces. TNBCs with high levels (IHC score ≥4) of PD-L1 included cases with (a) low number of CNVs (TNBC-33), b multiple focal high-level amplicons targeting known driver genes (TNBC 44 and TNBC-50), and (c) genomes with high CNV burdens (TNBC-14 and TNBC-23). PD-L1 IHC scores and location (T tumor cells, T/NT tumor plus non-tumor cells) as well as the DNA ploidy (N) of each TNBC are presented. The X and Y axes in the Comparative Genomic Hybridization plots represent chromosome and log2 ratios for each TNBC. Abbreviations: CNV copy number variant, IHC immunohistochemistry, TNBC triple-negative breast cancer