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Table 2 Brca1 deficiency promotes mammary tumor initiation

From: Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

Genotype p18 -/- -Donor A p18 -/- ;Brca1 MGKO - Donor A
Number of tumor cell transplanted a 1x107/mouse 1x106/mouse
Experiment number 1 2 1
Tumor incidence b (7 weeks) 0/6 3/6 (50%) c 4/4 (100%)
Genotype p18 -/- -Donor B p16 -/- ;Brca1 MGKO - Donor A
Number of tumor cell transplanted a 3x106/mouse 1x106/mouse
Experiment number 1 2 1
Tumor incidence (6 weeks) 0/6 1/4 (25%) c 4/4 (100%)
  1. aUnsorted primary tumor cells were used
  2. bTumors generated larger than 12mm3 in size were counted
  3. cTumor cells were transplanted into MFPs of NSG mice with E2 supplement. A statistical significance from E2-treated and non-E2 treated groups combining both p18-/--Donor A and -B transplants by two tailed Fisher Exact test