Table 1 Relationship between MMP13 and ETV4 transcripts levels and classical clinical biological parameters in 456 breast cancer samples
From: ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
Number of patients (%) | |||||
|---|---|---|---|---|---|
Total population (%) | Low ETV4 | High ETV4-Low MMP13 | High ETV4-High MMP13 | P valuea | |
Total | 456 (100.0) | 82 (18.0) | 255 (55.9) | 119 (26.1) | |
Age, yr | |||||
≤ 50 | 98 (21.5) | 10 (12.2) | 60 (23.5) | 28 (23.5) | 0.075 (NS) |
> 50 | 358 (78.5) | 72 (87.8) | 195 (76.5) | 91 (76.5) | |
SBR histological gradeb, c | |||||
I | 58 (13.0) | 10 (12.3) | 37 (15.0) | 11 (9.2) | 0.24 (NS) |
II | 229 (51.2) | 48 (59.3) | 122 (49.4) | 59 (49.6) | |
III | 160 (35.8) | 23 (28.4) | 88 (35.6) | 49 (41.2) | |
Lymph node statusd | |||||
0 | 119 (26.1) | 21 (25.9) | 67 (26.5) | 31 (26.3) | 0.085 (NS) |
1–3 | 237 (52.1) | 37 (45.7) | 144 (56.9) | 56 (47.5) | |
> 3 | 96 (21.8) | 23 (28.4) | 42 (16.6) | 31 (26.3) | |
Macroscopic tumor sizee | |||||
≤ 25 mm | 223 (49.8) | 40 (50.0) | 132 (52.4) | 51 (44.0) | 0.32 (NS) |
> 25 mm | 225 (50.2) | 40 (50.0) | 120 (47.6) | 65 (56.0) | |
ERα status | |||||
Negative | 118 (25.9) | 9 (11.0) | 67 (26.3) | 42 (35.3) | 0.00067 |
Positive | 338 (74.1) | 73 (89.0) | 188 (73.7) | 77 (64.7) | |
PR status | |||||
Negative | 194 (42.5) | 31 (37.8) | 103 (40.4) | 60 (50.4) | 0.12 (NS) |
Positive | 262 (57.5) | 51 (62.2) | 152 (59.6) | 59 (49.6) | |
ERBB2 status | |||||
Negative | 357 (78.3) | 71 (86.6) | 200 (78.4) | 86 (72.3) | 0.052 (NS) |
Positive | 99 (21.7) | 11 (13.4) | 55 (21.6) | 33 (27.7) | |
Molecular subtypes | |||||
HR−ERBB2− | 68 (14.9) | 8 (9.8) | 41 (16.1) | 19 (16.0) | 0.0015 |
HR−ERBB2+ | 45 (9.9) | 1 (1.2) | 22 (8.6) | 22 (18.5) | |
HR+ERBB2− | 289 (63.4) | 63 (76.8) | 159 (62.4) | 67 (56.3) | |
HR+ERBB2+ | 54 (11.8) | 10 (12.2) | 33 (12.9) | 11 (9.2) | |
PIK3CA mutation status | |||||
Wild type | 307 (67.3) | 56 (68.3) | 172 (67.5) | 79 (66.4) | 0.96 (NS) |
Mutated | 149 (32.7) | 26 (31.7) | 83 (32.5) | 40 (33.6) | |
MKI67 mRNA expression | |||||
Median | 12.5 (0.80–117) | 11.7 (1.74–117) | 12.1 (0.80–94.5) | 13.6 (2.1–58.5) | 0.073 (NS) |