Fig. 2

Results of the CEST analysis in the same patient as in Fig. 1 in the tumor ROI (see Table 1, patient 1). a Results of the three-pool Lorentzian fitting of the Z-spectrum of water (yellow line), magnetization transfer effect (MT; green line), amide proton transfer (APT; purple line), and the full fit consisting of the three fits (orange). b Mean Z-spectrum in the tumor before (blue) and after (red) the first cycle of neoadjuvant chemotherapy (NAC) treatment. The insert of the dashed box is shown in c, which shows the Lorentzian fit for the APT signal before (blue) and after (red) NAC treatment with the standard deviation of the APT signal of the voxels in the tumor ROIs, shown as the error bars