Fig. 4
From: A novel neuregulin – jagged1 paracrine loop in breast cancer transendothelial migration
Neuregulin (NRG1) knockdown reduces intravasation in vivo. Intravasation was measured in mice bearing orthotopic tumors carrying the control vector (shControl) or NRG1 shRNA constructs (shRNA1, shRNA2). Mice were fed with control (no dox) or diet containing doxycycline (with dox) to induce tumor expression of shRNA. Results are shown as the average number of tumor cells per 1 mL of blood. Data are means and SEM from least 11 animals per group; **p < 0.01,*p < 0.05, t test