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Table 2 Multivariable analysis of patient demographics and characteristics comparing patients who did not receive chemotherapy to patients who did receive chemotherapy

From: Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores

  Adjusted odds ratio 95% confidence interval p value
Facility type
 Community cancer program 1.26 1.07–1.49 0.01
 Comprehensive community cancer program 1.20 1.09–1.32 < 0.001
 Academic/research program REF   
 Other 1.13 0.95–1.33 0.16
Age category (years)
 < 40 REF   
 40–49 0.48 0.38–0.61 < 0.001
 50–59 0.34 0.27–0.43 < 0.001
 60–69 0.20 0.16–0.26 < 0.001
 70–79 0.10 0.07–0.14 < 0.001
 80+ 0.07 0.03–0.16 < 0.001
Race/ethnicity
 Non-Hispanic White REF   
 Non-Hispanic Black 1.10 0.94–1.40 0.26
 Hispanic 1.04 0.85–1.27 0.73
 Non-Hispanic Asian/Pacific 0.94 0.76–1.17 0.60
 Other 1.15 0.94–1.40 0.19
Primary payer
 Not insured 1.09 0.80–1.48 0.59
 Private insurance REF   
 Medicaid 0.91 0.76–1.09 0.30
 Medicare 0.73 0.63–0.85 < 0.001
 Other 0.79 0.58–1.08 0.14
Urban/rural
 Metro counties REF   
 Urban counties 0.87 0.76–1.00 0.05
 Rural counties 1.30 0.95–1.79 0.10
 Unknown 0.84 0.63–1.12 0.22
Charlson–Deyo score
 0 REF   
 1 1.09 0.95–1.24 0.22
 2 0.73 0.49–1.08 0.11
Grade
 Well differentiated, differentiated, NOS REF   
 Moderately differentiated, moderately well differentiated, intermediate differentiation 1.72 1.54–1.91 < 0.001
 Poorly differentiated 3.76 3.28–4.31 < 0.001
AJCC pathologic stage
 T1C REF   
 T2 1.62 1.48–1.77 < 0.001
Lymphovascular invasion
 Not present REF   
 Present 1.41 1.25–1.59 < 0.001
Type of surgery
 Breast conservation REF   
 Mastectomy 1.35 1.06–1.72 0.02
Margin status
 Negative REF   
 Positive 1.15 0.92–1.44 0.23
 Unknown 1.05 0.45–2.46 0.90
Radiation therapy
 None REF   
 Beam radiation 0.35 0.01–8.40 0.51
Radiation treatment volume
 No radiation treatment 0.25 0.01–6.20 0.40
 Breast or chest wall REF   
 Breast/lymph nodes or chest wall/lymph nodes 1.24 0.96–1.61 0.10
 Other 2.36 1.05–5.30 0.04
 Unknown 1.30 0.56–3.04 0.54
  1. AJCC American Joint Committee on Cancer, NOS not otherwise specified, REF reference
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