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Table 2 Associations between leukocyte telomere length and breast cancer risk

From: Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Stratum

Relative LTLa

Controls

Cases

OR

95% CI

p value

Overall

Quartile 1 (0.36–0.63)

134

81

Reference

 

Quartile 2 (0.63–0.75)

126

102

1.60

(1.04–2.46)

3.17E-02

 

Quartile 3 (0.75–0.93)

134

172

2.28

(1.46–3.57)

2.89E-04

 

Quartile 4 (0.93–1.94)

139

215

2.71

(1.58–4.65)

3.07E-04

 

Continuous variable

533

570

3.20

(1.57–6.55)

1.41E-03

ER+

Quartile 1 (0.36–0.63)

134

41

Reference

 

Quartile 2 (0.63–0.75)

126

45

1.59

(0.88–2.89)

1.25E-01

 

Quartile 3 (0.75–0.93)

134

77

2.97

(1.54–5.72)

1.11E-03

 

Quartile 4 (0.93–1.94)

139

86

2.55

(1.10–5.86)

2.82E-02

 

continuous variable

533

249

3.33

(1.17–9.46)

2.38E-02

ER−

Quartile 1 (0.36–0.63)

134

28

Reference

 

Quartile 2 (0.63–0.75)

126

40

1.25

(0.65–2.44)

5.05E-01

 

Quartile 3 (0.75–0.93)

134

79

1.67

(0.88–3.16)

1.19E-01

 

Quartile 4 (0.93–1.94)

139

104

2.12

(1.04–4.31)

3.84E-02

 

Continuous variable

533

251

2.33

(0.88–6.15)

8.92E-02

  1. ER Estrogen receptor, LTL Leukocyte telomere length
  2. aAnalyses are adjusted for age, body mass index, smoking, center of origin, and plate