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Table 4 Univariate and multivariate Cox’s regression analysis of the combined IDH1 and Snail for disease-specific survival and disease-free survival of breast IDC patients

From: Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Variable (n = 234) Number (percentage) Disease-specific survival Disease-free survival
CHR* (95% CI) p value AHR** (95% CI) p value CHR* (95% CI) p value AHR** (95% CI) p value
IDH1 high, snail low 104 (44.4) 1.00   1.00   1.00   1.00  
IDH1 high, snail high 49 (20.9) 1.10 (0.64–1.88) 0.725 1.15 (0.67–1.97) 0.624 1.30 (0.75–2.23) 0.349 1.31 (0.76–2.27) 0.331
IDH1 low, snail low 50 (21.4) 1.63 (1.01–2.64) 0.047 1.44 (0.88–2.36) 0.151 1.49 (0.88–2.54) 0.142 1.23 (0.72–2.13) 0.450
IDH1 low, snail high 31 (13.3) 2.10 ( 1.22 3.63 ) 0.008 2.34 ( 1.32 4.16 ) 0.004 2.49 ( 1.42 4.37 ) 0.001 2.50 ( 1.39–4.50 ) 0.002
   p for linear trend 0.004 p for linear trend 0.006 p for linear trend 0.002 p for linear trend 0.011
  1. Abbreviations: IDH1 isocitrate dehydrogenase 1, IDC invasive ductal carcinoma, CHR crude hazard ratio, AHR adjusted hazard ratio
  2. *CHRs were estimated by univariate Cox regression
  3. **AHRs were adjusted for American Joint Committee on Cancer pathological stage (II and III vs. I), grading (III vs. I and II), incomplete or inappropriate adjuvant treatment vs. non-treatment or complete adjuvant treatment, and molecular subtypes (luminal B, human epidermal growth factor receptor 2 (Her2) overexpression and basal-like vs. luminal A) by multivariate Cox regression
  4. Bold italic values denote statistically significant
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