Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Table 4 Univariate and multivariate Cox’s regression analysis of the combined IDH1 and Snail for disease-specific survival and disease-free survival of breast IDC patients

Variable (n = 234)	Number (percentage)	Disease-specific survival				Disease-free survival
Variable (n = 234)	Number (percentage)	CHR^* (95% CI)	p value	AHR^** (95% CI)	p value	CHR^* (95% CI)	p value	AHR^** (95% CI)	p value
IDH1 high, snail low	104 (44.4)	1.00		1.00		1.00		1.00
IDH1 high, snail high	49 (20.9)	1.10 (0.64–1.88)	0.725	1.15 (0.67–1.97)	0.624	1.30 (0.75–2.23)	0.349	1.31 (0.76–2.27)	0.331
IDH1 low, snail low	50 (21.4)	1.63 (1.01–2.64)	*0.047*	1.44 (0.88–2.36)	0.151	1.49 (0.88–2.54)	0.142	1.23 (0.72–2.13)	0.450
IDH1 low, snail high	31 (13.3)	*2.10* ( *1.22* – *3.63* )	*0.008*	*2.34* ( *1.32* – *4.16* )	*0.004*	*2.49* ( *1.42* – *4.37* )	*0.001*	*2.50* ( *1.39–4.50* )	*0.002*
		p for linear trend	*0.004*	p for linear trend	0.006	p for linear trend	*0.002*	p for linear trend	0.011

Abbreviations: IDH1 isocitrate dehydrogenase 1, IDC invasive ductal carcinoma, CHR crude hazard ratio, AHR adjusted hazard ratio
*CHRs were estimated by univariate Cox regression
**AHRs were adjusted for American Joint Committee on Cancer pathological stage (II and III vs. I), grading (III vs. I and II), incomplete or inappropriate adjuvant treatment vs. non-treatment or complete adjuvant treatment, and molecular subtypes (luminal B, human epidermal growth factor receptor 2 (Her2) overexpression and basal-like vs. luminal A) by multivariate Cox regression
Bold italic values denote statistically significant

ISSN: 1465-542X