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Table 2 Clinical and histological features of ATM-associated invasive breast carcinomas compared with those of sporadic cases

From: Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers

Clinicopathological variable PICBIM series (N = 516) ATM series (all tumours, TV + MS) (N = 36) P value a ATM series (1st primary tumours only) (N = 32) P value a ATM series (excluding MS in HBOC families) (N = 31) P value a
Histological subtype
 Ductal carcinoma 434 30 Reference 27 Reference 25 Reference
 Lobular carcinoma 54 2 0.55 2 0.69 2 0.78
 Others 28 3 0.43 2 0.78 3 0.25
 Unknown 0 1 1 1
Histological grade
 I 88 4 Reference 3 Reference 4 Reference
 II 191 16 0.34 15 0.24 13 0.58
 III 236 15 0.64 13 0.55 14 0.75
 Unknown 1 1 1
Architecture
 1–2 126 0 Reference 7 Reference 6 Reference
 3 390 30 0.97 21 0.86 20 0.96
 Unknown 0 6 4 5
Mitosis
 0–1 221 15 Reference 14 Reference 12 Reference
 2 103 9 0.58 8 0.70 9 0.31
 3 191 6 0.10 6 0.13 5 0.15
 Unknown 1 6 4 5
Nuclear grade
 1 30 2 Reference 2 Reference 2 Reference
 2 225 7 0.25 7 0.22 5 0.12
 3 261 21 0.96 19 0.89 19 0.9
 Unknown 0 6 4 5
Tumour size (cm)
 pT1 (< 2) 329 23 Reference 20 Reference 19 Reference
 pT2 (2–5) 166 8 0.37 7 0.41 7 0.48
 pT3 (> 5) 14 2 0.37 2 0.30 2 0.26
 pT4 7 0 0 0
 Unknown 0 3 3 3
Pushing margins
 Absent 461 19 Reference 17 Reference 15 Reference
 Present 49 2 0.98 2 0.93 2 0.78
 Unknown 6 15 13 14
Emboli
 Absent 315 13 Reference 11 Reference 13 Reference
 Present 199 14 0.08 14 0.04 11 0.32
 Unknown 2 9 7 7
N stage
 pN0 286 18 Reference 15 Reference 15 Reference
 pN1 151 10 0.80 9 0.66 9 0.55
 pN2 59 1 0.23 1 0.32 1 0.35
 pN3 16 1 0.96 1 0.81 1 0.76
 pNx 5 6 6 5
Oestrogen receptor
 Positive 307 34 Reference 31 Reference 29 Reference
 Negative 209 1 0.003 1 0.004 1 0.005
 Unknown 0 1 1
Progesterone receptor
 Positive 278 26 Reference 23 Reference 23 Reference
 Negative 236 8 0.03 8 0.07 6 0.02
 Unknown 2 2 1 2
HER2
 Negative 433 25 Reference 23 Reference 21 Reference
 Positive 83 6 0.77 5 0.97 6 0.53
 Unknown 0 5 4 4
Ki-67
 < 20% 173 11 Reference 10 Reference 8 Reference
 ≥ 20% 336 18 0.55 17 0.59 17 0.97
 Unknown 7 7 5 6
Molecular subtype
 TNBC 142 1 Reference 1 Reference 1 Reference
 HER2 66 0 N/A 0 N/A 0 N/A
 Luminal A 180 10 0.06 9 0.08 7 0.13
 Luminal B 111 13 0.009 12 0.010 12 0.010
 Luminal B/HER2 17 4 0.005 4 0.005 4 0.005
 Unknown 0 8 6 7
  1. Abbreviations: ATM, Ataxia-telangiectasia mutated, HBOC Hereditary breast and ovarian cancer, HER2 Human epidermal growth factor receptor 2, MS Missense substitution, PICBIM Programme incitatif et collaboratif - Cancer du sein: invasion et motilité series, TV Truncating variant, TNBC Triple-negative breast cancer
  2. a P value adjusted for sex and for age at diagnosis