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Table 2 Clinical and histological features of ATM-associated invasive breast carcinomas compared with those of sporadic cases

From: Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers

Clinicopathological variable

PICBIM series (N = 516)

ATM series (all tumours, TV + MS) (N = 36)

P value a

ATM series (1st primary tumours only) (N = 32)

P value a

ATM series (excluding MS in HBOC families) (N = 31)

P value a

Histological subtype

 Ductal carcinoma

434

30

Reference

27

Reference

25

Reference

 Lobular carcinoma

54

2

0.55

2

0.69

2

0.78

 Others

28

3

0.43

2

0.78

3

0.25

 Unknown

0

1

–

1

–

1

–

Histological grade

 I

88

4

Reference

3

Reference

4

Reference

 II

191

16

0.34

15

0.24

13

0.58

 III

236

15

0.64

13

0.55

14

0.75

 Unknown

1

1

–

1

–

–

–

Architecture

 1–2

126

0

Reference

7

Reference

6

Reference

 3

390

30

0.97

21

0.86

20

0.96

 Unknown

0

6

–

4

–

5

–

Mitosis

 0–1

221

15

Reference

14

Reference

12

Reference

 2

103

9

0.58

8

0.70

9

0.31

 3

191

6

0.10

6

0.13

5

0.15

 Unknown

1

6

–

4

–

5

–

Nuclear grade

 1

30

2

Reference

2

Reference

2

Reference

 2

225

7

0.25

7

0.22

5

0.12

 3

261

21

0.96

19

0.89

19

0.9

 Unknown

0

6

–

4

–

5

–

Tumour size (cm)

 pT1 (< 2)

329

23

Reference

20

Reference

19

Reference

 pT2 (2–5)

166

8

0.37

7

0.41

7

0.48

 pT3 (> 5)

14

2

0.37

2

0.30

2

0.26

 pT4

7

0

–

0

–

0

–

 Unknown

0

3

–

3

–

3

–

Pushing margins

 Absent

461

19

Reference

17

Reference

15

Reference

 Present

49

2

0.98

2

0.93

2

0.78

 Unknown

6

15

–

13

–

14

–

Emboli

 Absent

315

13

Reference

11

Reference

13

Reference

 Present

199

14

0.08

14

0.04

11

0.32

 Unknown

2

9

–

7

–

7

–

N stage

 pN0

286

18

Reference

15

Reference

15

Reference

 pN1

151

10

0.80

9

0.66

9

0.55

 pN2

59

1

0.23

1

0.32

1

0.35

 pN3

16

1

0.96

1

0.81

1

0.76

 pNx

5

6

–

6

–

5

–

Oestrogen receptor

 Positive

307

34

Reference

31

Reference

29

Reference

 Negative

209

1

0.003

1

0.004

1

0.005

 Unknown

0

1

–

–

–

1

–

Progesterone receptor

 Positive

278

26

Reference

23

Reference

23

Reference

 Negative

236

8

0.03

8

0.07

6

0.02

 Unknown

2

2

–

1

–

2

–

HER2

 Negative

433

25

Reference

23

Reference

21

Reference

 Positive

83

6

0.77

5

0.97

6

0.53

 Unknown

0

5

–

4

–

4

–

Ki-67

 < 20%

173

11

Reference

10

Reference

8

Reference

 ≥ 20%

336

18

0.55

17

0.59

17

0.97

 Unknown

7

7

–

5

–

6

–

Molecular subtype

 TNBC

142

1

Reference

1

Reference

1

Reference

 HER2

66

0

N/A

0

N/A

0

N/A

 Luminal A

180

10

0.06

9

0.08

7

0.13

 Luminal B

111

13

0.009

12

0.010

12

0.010

 Luminal B/HER2

17

4

0.005

4

0.005

4

0.005

 Unknown

0

8

–

6

–

7

–

  1. Abbreviations: ATM, Ataxia-telangiectasia mutated, HBOC Hereditary breast and ovarian cancer, HER2 Human epidermal growth factor receptor 2, MS Missense substitution, PICBIM Programme incitatif et collaboratif - Cancer du sein: invasion et motilité series, TV Truncating variant, TNBC Triple-negative breast cancer
  2. a P value adjusted for sex and for age at diagnosis
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Breast Cancer Research

ISSN: 1465-542X

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