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Table 5 Mean percentages of pathological response per MRI-based response pattern (mean percentage of reader 1 and 2) halfway through and after NAC

From: MRI-based response patterns during neoadjuvant chemotherapy can predict pathological (complete) response in patients with breast cancer

 

MRI halfway through NAC

MRI after NAC

Percentage of total (N = 75)

Tumor response > 50%

Diameter reduction > 50%

pCR

Percentage of total (N = 57)

Tumor response > 50%

Diameter reduction > 50%

pCR

Complete radiologic response (type 0)

8%

90%

83%

83%

20%

96%

61%

41%

Concentric shrinkage (type 1)

40%

78%

37%

26%

24%

61%

44%

18%

Crumbling (type 2)

30%

65%

40%

14%

23%

69%

43%

8%

Diffuse enhancement (type 3)

2%

n.a.

n.a.

n.a.

9%

n.a.

n.a.

n.a.

Stable disease (type 4)

21%

53%

39%

3%

24%

38%

11%

4%

Progressive disease (type 5)

1%

n.a.

n.a.

n.a.

2%

50%

0%

0%

Total

100%

69%

41%

21%

100%

65%

38%

16%

  1. Abbreviations: MRI magnetic resonance imaging, NAC neoadjuvant chemotherapy and immunotherapy, pCR pathological complete response, n.a. not applicable