Table 3 Association of SLC7A5 protein expression and the expression of other molecular biomarkers in the discovery and validation sets
SLC7A5 protein | ||||||||
|---|---|---|---|---|---|---|---|---|
Discovery set | Validation set | |||||||
| Â | Number (%) | Mean | p value | Adjusted p value | Number (%) | Mean | p value | Adjusted p value |
ER | ||||||||
 Negative | 270 (25) | 722.20 | 3.2 × 10−48 | <0.0001 | 300 (19) | 1094.70 | 4.6 × 10−76 | <0.0001 |
 Positive | 827 (75) | 492.45 | 1240 (81) | 692.06 | ||||
PgR | ||||||||
 Negative | 435 (41) | 619.12 | 8.8 × 10−27 | <0.0001 | 612 (42) | 855.53 | 1.3 × 10−34 | <0.0001 |
 Positive | 630 (59) | 473.54 | 853 (58) | 645.09 | ||||
HER2 | ||||||||
 Negative | 921 (87) | 521.78 | 0.00004 | 0.0001 | 1337 (92) | 718.53 | 0.001 | 0.002 |
 Positive | 143 (13) | 601.54 | 116 (8) | 824.67 | ||||
Triple negative | ||||||||
 No | 896 (83) | 503.50 | 4.5 × 10−35 | <0.0001 | 1286 (83) | 696.76 | 1.5 × 10−62 | <0.0001 |
 Yes | 185 (17) | 722.61 | 225 (17) | 1094.6 | ||||
Basal phenotype | ||||||||
 No | 794 (74) | 510.96 | 6.8 × 10−13 | <0.0001 | N/A | |||
 Yes | 285 (26) | 620.90 | ||||||
P53 protein | ||||||||
 Negative | 760 (72) | 499.14 | 4.1 × 10−13 | <0.0001 | N/A | |||
 Positive | 298 (28) | 606.92 | ||||||