Table 1 Clinicopathological associations of SLC7A5 protein expression in the discovery and validation breast cancer series
SLC7A5 protein | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Discovery set | Validation set | |||||||||
| Â | Number (%) | Mean | p value | Adjusted p value | Number (%) | Mean | p value | Adjusted p value | ||
Patient’s age (years) | ||||||||||
 ≥50 | 395 (36) | 582.20 | 0.003 | 0.018 | 469 (30) | 859.46 | 7.0 × 10−12 | <0.0001 | ||
 <50 | 714 (64) | 539.95 | 1070 (70) | 730.79 | ||||||
Tumour size | ||||||||||
 ≥2.0 cm | 532 (48) | 521.22 | 0.000002 | <0.0001 | 939 (61) | 729.47 | 6.5 × 10−9 | <0.0001 | ||
 ˂2.0 cm | 577 (52) | 586.14 | 599 (39) | 832.24 | ||||||
Lympho-vascular invasion | ||||||||||
 Negative | 722 (65) | 545.17 | 0.138 | 0.55 | 1086 (71) | 743.95 | 0.000007 | <0.0001 | ||
 Positive | 382 (35) | 566.35 | 451 (29) | 829.31 | ||||||
Site of distant metastasis | ||||||||||
 Brain | ||||||||||
  No | 1044 (94) | 546.62 | 0.0001 | 0.0008 | N/A | |||||
  Yes | 61 (6) | 662.27 | ||||||||
 Lung | ||||||||||
  No | 1003 (91) | 547.12 | 0.007 | 0.04 | N/A | |||||
  Yes | 102 (9) | 610.80 | ||||||||
 Bone | ||||||||||
  No | 876 (79) | 554.57 | 0.651 | 1.30 | N/A | |||||
  Yes | 229 (21) | 547.00 | ||||||||
 Liver | ||||||||||
  No | 949 (86) | 551.43 | 0.568 | 1.70 | N/A | |||||
  Yes | 156 (14) | 562.57 | ||||||||
|  | Number (%) | Mean | χ2 | p value | Adjusted p value | Number (%) | Mean | χ2 | p value | Adjusted p value |
Tumour grade | ||||||||||
 1 | 190 (17) | 450.77 | 171.5 | 5.6 × 10−38 | <0.0001 | 231 (15) | 585.30 | 723.48 | 7.7 × 10−72 | <0.0001 |
 2 | 366 (33) | 473.19 | 622 (40) | 647.46 | ||||||
 3 | 550 (50) | 642.43 | 685 (45) | 942.43 | ||||||
Lymph node stage | ||||||||||
 1 | 674 (61) | 542.19 | 4.811 | 0.09 | 0.45 | 955 (62) | 754.30 | 12.56 | 0.002 | 0.004 |
 2 | 341 (31) | 574.98 | 428 (28) | 767.94 | ||||||
 3 | 91 (8) | 556.75 | 153 (10) | 858.69 | ||||||
Nottingham Prognostic Index | ||||||||||
 Good | 332 (30) | 458.21 | 102.4 | 5.6 × 10−23 | <0.0001 | 521 (34) | 620.66 | 156.60 | 9.8 × 10−35 | <0.0001 |
 Moderate | 593 (53) | 578.27 | 768 (50) | 828.08 | ||||||
 Poor | 184 (17) | 654.64 | 246 (16) | 892.49 | ||||||
IHC subtypes | ||||||||||
 ER+/HER2- low proliferation | 250 (27) | 391.92 | 178.4 | 1.8 × 10−38 | <0.0001 | N/A | ||||
 ER+/HER2- high proliferation | 351 (38) | 419.54 | ||||||||
 Triple negative | 191 (20) | 617.95 | ||||||||
 HER2+ | 143 (15) | 519.69 | ||||||||
Histological type | ||||||||||
 Ductal (including mixed) | 922 (83) | 563.83 | 69.05 | 3.5 × 10−14 | <0.0001 | 1335 (87) | 782.19 | 77.07 | 7.2 × 10−16 | <0.0001 |
 Lobular | 101 (9) | 454.17 | 120 (8) | 584.17 | ||||||
 Medullary | 26 (2) | 832.02 | 13 (0.8) | 1257.27 | ||||||
 Miscellaneous | 7 (0.6) | 440.50 | 9 (0.6) | 1037.78 | ||||||
 Special type | 53 (5.4) | 472.75 | 57 (3.6) | 655.12 | ||||||