Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer

Table 4 Discrimination of the Pubertal Development Scale and Sexual Maturation Scale compared with clinical Tanner stage, as assessed by AUC in the LEGACY Girls Study

	Clinical Tanner stage (T1 vs T2+) AUC (n = 153)	Clinical Tanner stage (T1 vs T2) AUC (n = 153)
Model A
PDS^a	0.88	0.84
E1G (ng/ml)	0.91	0.87
Race/ethnicity	0.89	0.86
Height (% for age)	0.89	0.84
Weight (% for age)	0.88	0.84
Overweight (> 85th percentile BMI)	0.90	0.86
Family history	0.87	0.83
SMS^b	0.78	0.68
E1G (ng/ml)	0.86	0.79
Race/ethnicity	0.81	0.70
Height (% for age)	0.78	0.68
Weight (% for age)	0.78	0.68
Overweight (≥ 85th percentile BMI)	0.80	0.69
Family history	0.78	0.68
Model B
PDS^a	0.88	0.84
+ E1G (ng/ml)	0.91	0.87
+ Race/ethnicity	0.91	0.88
+ Overweight (> 85th percentile BMI)	0.92	0.88
+ Family history	0.92	0.88
SMS^b	0.78	0.68
+ E1G (ng/ml)	0.86	0.79
+ Race/ethnicity	0.86	0.80
+ Overweight (> 85th percentile BMI)	0.87	0.80
+ Family history	0.87	0.80
Model C
PDS, SMS, E1G	0.91	0.87

Abbreviations: BMI Body mass index, E1G Estrone 1-glucuronide, PDS Pubertal Development Scale, SMS Sexual Maturation Scale
Model A: These models compare mother’s report (PDS or SMS) with clinical TS and add each covariate one at a at time
Model B: These models compare mother’s report (PDS or SMS) with clinical TS and are nested so that each subsequent covariate is added to the previous model
Model C: This model includes PDS, SMS, and E1G to test if the combination of all three measures yields a higher AUC than either PDS + E1G or SMS + E1G
^aPDS is a questionnaire-based assessment of breast development without pictures
^bSMS is a questionnaire-based assessment of breast development that uses pictures to illustrate the five Tanner Stages of breast development

ISSN: 1465-542X