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Table 4 Discrimination of the Pubertal Development Scale and Sexual Maturation Scale compared with clinical Tanner stage, as assessed by AUC in the LEGACY Girls Study

From: Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer

  Clinical Tanner stage (T1 vs T2+) AUC (n = 153) Clinical Tanner stage (T1 vs T2) AUC (n = 153)
Model A
 PDSa 0.88 0.84
  E1G (ng/ml) 0.91 0.87
  Race/ethnicity 0.89 0.86
  Height (% for age) 0.89 0.84
  Weight (% for age) 0.88 0.84
  Overweight (> 85th percentile BMI) 0.90 0.86
  Family history 0.87 0.83
 SMSb 0.78 0.68
  E1G (ng/ml) 0.86 0.79
  Race/ethnicity 0.81 0.70
  Height (% for age) 0.78 0.68
  Weight (% for age) 0.78 0.68
  Overweight (≥ 85th percentile BMI) 0.80 0.69
  Family history 0.78 0.68
Model B
 PDSa 0.88 0.84
   + E1G (ng/ml) 0.91 0.87
   + Race/ethnicity 0.91 0.88
   + Overweight (> 85th percentile BMI) 0.92 0.88
   + Family history 0.92 0.88
 SMSb 0.78 0.68
   + E1G (ng/ml) 0.86 0.79
   + Race/ethnicity 0.86 0.80
   + Overweight (> 85th percentile BMI) 0.87 0.80
   + Family history 0.87 0.80
Model C
 PDS, SMS, E1G 0.91 0.87
  1. Abbreviations: BMI Body mass index, E1G Estrone 1-glucuronide, PDS Pubertal Development Scale, SMS Sexual Maturation Scale
  2. Model A: These models compare mother’s report (PDS or SMS) with clinical TS and add each covariate one at a at time
  3. Model B: These models compare mother’s report (PDS or SMS) with clinical TS and are nested so that each subsequent covariate is added to the previous model
  4. Model C: This model includes PDS, SMS, and E1G to test if the combination of all three measures yields a higher AUC than either PDS + E1G or SMS + E1G
  5. aPDS is a questionnaire-based assessment of breast development without pictures
  6. bSMS is a questionnaire-based assessment of breast development that uses pictures to illustrate the five Tanner Stages of breast development
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