| |
Clinical Tanner stage (T1 vs T2+) AUC (n = 153)
|
Clinical Tanner stage (T1 vs T2) AUC (n = 153)
|
|---|
|
Model A
|
|
PDSa
|
0.88
|
0.84
|
|
E1G (ng/ml)
|
0.91
|
0.87
|
|
Race/ethnicity
|
0.89
|
0.86
|
|
Height (% for age)
|
0.89
|
0.84
|
|
Weight (% for age)
|
0.88
|
0.84
|
|
Overweight (> 85th percentile BMI)
|
0.90
|
0.86
|
|
Family history
|
0.87
|
0.83
|
|
SMSb
|
0.78
|
0.68
|
|
E1G (ng/ml)
|
0.86
|
0.79
|
|
Race/ethnicity
|
0.81
|
0.70
|
|
Height (% for age)
|
0.78
|
0.68
|
|
Weight (% for age)
|
0.78
|
0.68
|
|
Overweight (≥ 85th percentile BMI)
|
0.80
|
0.69
|
|
Family history
|
0.78
|
0.68
|
|
Model B
|
|
PDSa
|
0.88
|
0.84
|
|
+ E1G (ng/ml)
|
0.91
|
0.87
|
|
+ Race/ethnicity
|
0.91
|
0.88
|
|
+ Overweight (> 85th percentile BMI)
|
0.92
|
0.88
|
|
+ Family history
|
0.92
|
0.88
|
|
SMSb
|
0.78
|
0.68
|
|
+ E1G (ng/ml)
|
0.86
|
0.79
|
|
+ Race/ethnicity
|
0.86
|
0.80
|
|
+ Overweight (> 85th percentile BMI)
|
0.87
|
0.80
|
|
+ Family history
|
0.87
|
0.80
|
|
Model C
|
|
PDS, SMS, E1G
|
0.91
|
0.87
|
- Abbreviations: BMI Body mass index, E1G Estrone 1-glucuronide, PDS Pubertal Development Scale, SMS Sexual Maturation Scale
- Model A: These models compare mother’s report (PDS or SMS) with clinical TS and add each covariate one at a at time
- Model B: These models compare mother’s report (PDS or SMS) with clinical TS and are nested so that each subsequent covariate is added to the previous model
- Model C: This model includes PDS, SMS, and E1G to test if the combination of all three measures yields a higher AUC than either PDS + E1G or SMS + E1G
- aPDS is a questionnaire-based assessment of breast development without pictures
- bSMS is a questionnaire-based assessment of breast development that uses pictures to illustrate the five Tanner Stages of breast development
