Table 1 Subject characteristics of the nationwide cohort and KARMA cohort
From: Inherited factors contribute to an inverse association between preeclampsia and breast cancer
| Â | No. of women (%) | |
|---|---|---|
Variable names | Non-PE | PE patients |
Nationwide cohort | ||
 Number of women | 1,270,353 | 67,581 |
Age at first birth | ||
 <25 | 518,407 (40.8) | 27,733 (41.0) |
 25-30 | 467,368 (36.8) | 23,967 (35.5) |
 30-35 | 216,920 (17.1) | 11,638 (17.2) |
 >35 | 67,658 (5.33) | 4243 (6.28) |
Number of births | ||
 1 | 348,710 (27.5) | 16,650 (24.6) |
 2 | 614,068 (48.3) | 32,128 (47.5) |
 >=3 | 307,575 (24.2) | 18,803 (27.8) |
Weight status (by BMI) | ||
 Underweight (<18.5) | 39,033 (4.21) | 1136 (2.18) |
 Healthy weight (18.5-24.9) | 636,349 (68.7) | 27,641 (53.1) |
 Overweight (25.0-29.9) | 186,711 (20.2) | 14,461 (27.8) |
 Obese ( ≥30.0) | 64,726 (6.98) | 8775 (16.9) |
Smoking status (cigarettes/day) | ||
 No | 670,294 (80.1) | 40,015 (85.6) |
 1-9 cigarettes | 112,104 (13.4) | 4675 (10.0) |
 >9 cigarettes | 54,543 (6.52) | 2068 (4.42) |
Education Level | ||
 Elementary | 135,442 (10.7) | 7000 (10.4) |
 Intermediate | 615,696 (48.5) | 34,978 (51.8) |
 College | 499,481 (39.3) | 24,939 (36.9) |
 Other | 19,734 (1.55) | 664 (0.98) |
KARMA cohort | ||
Number of women | 52,222 | 2822 |
Mean age at mammography (SD) | 55.3 (9.9) | 53.2 (9.2) |
Average percent mammographic density (SD) | 22.3 (19.5) | 19.3 (18.9) |
Menopausal status at mammography | ||
 Pre-menopausal | 20,774 (39.8) | 1335 (47.3) |
 Peri-menopausal | 1779 (3.41) | 138 (4.89) |
 Post-menopausal | 29,669 (56.8) | 1349 (47.8) |
Age at first birth | ||
 <25 | 17,666 (33.8) | 938 (33.2) |
 25-30 | 18,594 (35.6) | 942 (33.4) |
 30-35 | 11,072 (21.2) | 606 (21.5) |
 >35 | 4890 (9.36) | 336 (11.9) |
Number of births | ||
 1 | 8843 (16.9) | 448 (15.9) |
 2 | 28,741 (55.0) | 1469 (52.1) |
 >=3 | 14,638 (28.0) | 905 (32.1) |
Weight status (by BMI) | ||
 Underweight (<18.5) | 486 (0.93) | 22 (0.78) |
 Healthy weight (18.5-24.9) | 28,860 (55.3) | 1194 (42.3) |
 Overweight (25.0-29.9) | 16,482 (31.6) | 1011 (35.8) |
 Obese ( ≥30.0) | 6215 (11.9) | 583 (20.7) |
Smoking status (cigarettes/day) | ||
 No | 5172 (9.90) | 302 (10.7) |
 1-9 cigarettes | 13,425 (25.7) | 625 (22.2) |
 >9 cigarettes | 8926 (17.1) | 445 (15.8) |
Education Level | ||
 Elementary | 3933 (7.55) | 171 (6.07) |
 Intermediate | 16,176 (31.1) | 998 (35.4) |
 College | 26,861 (51.6) | 1465 (52.0) |
 Other | 5105 (9.80) | 184 (6.53) |
Alcohol use | ||
 Never | 9566 (18.5) | 700 (24.9) |
 0-5g/day | 13,666 (26.4) | 697 (24.8) |
 5-10g/day | 18,553 (35.8) | 980 (34.9) |
 >10g/day | 10,071 (19.4) | 435 (15.5) |
Age at menarche | ||
 <12 | 17,325 (33.9) | 1133 (41.0) |
 13-16 | 31,272 (61.1) | 1531 (55.4) |
 >16 | 2576 (5.03) | 102 (3.69) |
Body shape at age 18* | ||
 1 | 2328 (4.46) | 130 (4.61) |
 2 | 12,644 (24.2) | 557 (19.7) |
 3 | 19,074 (36.5) | 952 (33.7) |
 4 | 12,990 (24.9) | 805 (28.5) |
 5~9 | 5025 (9.62) | 374 (13.3) |
Hours of Physical activity at age 18 (per week) | ||
 <1 | 8356 (17.4) | 458 (17.7) |
 1-2 | 14,193 (29.5) | 725 (28.0) |
 3-5 | 14,082 (29.3) | 776 (30.0) |
 ≥5 | 11,459 (23.8) | 628 (24.3) |
Irregular menstrual cycle in adult life | ||
 No | 45,465 (87.1) | 2382 (84.4) |
 Yes | 5799 (11.1) | 391 (13.9) |