Evaluating the breast cancer predisposition role of rare variants in genes associated with low-penetrance breast cancer risk SNPs

Table 1 Candidate genes identified and corresponding breast cancer risk single-nucleotide polymorphisms

SNP	GWAS proposed candidates	Neighbouring genes ± 500 kb	SNP	GWAS proposed candidates	Neighbouring genes ± 500 kb
rs7726159	TERT	–	rs2016394	–	DLX2
rs10069690	TERT	–	rs1550623	CDCA7	–
rs2736108	TERT	–	rs6762644	–	SETMAR; ITPR1
rs2588809	RAD51B	–	rs12493607	TGFBR2	–
rs999737	RAD51B	–	rs9790517	TET2	–
rs10759243	–	RAD23B	rs6828523	ADAM29	–
rs2981579	FGFR2	–	rs1353747	PDE4D	–
rs11199914	–	FGFR2	rs1432679	EBF1	–
rs7072776	DNAJC1	–	rs204247	RANBP9	–
rs11814448	DNAJC1	–	rs720475	–	TPK1
rs13387042	–	TNP1	rs6472903	–	HNF4G
rs11552449	–	DCLRE1B	rs2943559	HNF4G	–
rs1045485	CASP8	–	rs7904519	TCF7L2	–
rs4973768	SLC4A7	–	rs3903072	–	KAT5; SNX32; MUS81
rs889312	MAP3K1	–	rs11820646	–	NFRKB
rs12662670	ESR1	–	rs2236007	PAX9	–
rs2046210	ESR1	–	rs941764	CCDC88C	–
rs1011970	CDKN2A; CDKN2B	–	rs17817449	FTO	–
rs704010	ZMIZ1	–	rs13329835	CDYL2	–
rs3817198	LSP1	–	rs527616	–	CHST9
rs10771399	PTHLH	–	rs1436904	CHST9	–
rs3803662	TOX3	–	rs4808801	ELL	–
rs6504950	COX11	–	rs3760982	–	XRCC1; KCNN4; ZNF283; ZNF226
rs8170	–	USHBP1; BABAM1; UNC13A	rs132390	–	EMID1; NF2
rs2363956	–	USHBP1; BABAM1; UNC13A	rs6001930	MKL1	–
rs2823093	NRIP1	–	rs4245739	MDM4	–
rs616488	PEX14	–	rs6678914	LGR6	–
rs4849887	–	EPB41L5	rs11075995	FTO	–

ISSN: 1465-542X