Table 2 Gene transcripts differentially expressed in the metastasis of WHIM17 lineage mice relative to both control mice and primary xenograft tumor
Gene symbol | Gene name | Fold expression | p value | Targetable |
|---|---|---|---|---|
ALB | Albumin | 97.6 | 2.77E-08 | Â |
IGF2 | Insulin-like growth factor 2 | 46.0 | 1.12E-06 | Â |
FABP1 | Fatty acid binding protein 1 | 37.0 | 3.21E-07 | Â |
GPC3 | Glypican 3 | 24.9 | 5.78E-09 | |
DCT | Dopachrome tautomerase | 21.3 | 2.15E-07 | Â |
SPP1 | Secreted phosphoprotein 1 | 16.7 | 1.18E-07 | Â |
FGG | Fibrinogen gamma chain | 16.5 | 2.56E-07 | Â |
FGA | Fibrinogen alpha chain | 15.8 | 1.67E-07 | Â |
MAL2 | Mal, T-cell differentiation protein 2 | 14.2 | 3.75E-08 | Â |
APOB | Apolipoprotein B | 12.2 | 2.62E-07 | Â |
CPE | Carboxypeptidase E | 10.7 | 1.11E-06 | Â |
BAMBI | BMP and activin membrane bound inhibitor | 9.6 | 0.00021247 | Â |
TYR | Tyrosinase | 9.4 | 3.52E-07 | Â |
BCHE | Butyrylcholinesterase | 8.8 | 1.02E-06 | Â |
CD24 | CD24 molecule | 8.7 | 1.55E-05 | Â |
LEF1 | Lymphoid enhancer binding factor 1 | 8.2 | 0.0001236 | Â |
TSPAN8 | Tetraspanin 8 | 6.8 | 9.95E-06 | Â |
SERPINA1 | Serpin family A member 1 | 6.2 | 2.00E-05 | Â |
CGA | Glycoprotein hormones, alpha polypeptide | 6.2 | 7.70E-05 | Â |
AZGP1 | Alpha-2-glycoprotein 1, zinc-binding | 6.2 | 0.00126944 | Â |
TFF1 | Trefoil factor 1 | 6.2 | 3.83E-05 | Â |
HGD | Homogentisate 1,2-dioxygenase | 5.9 | 6.49E-05 | Â |
TYRP1 | Tyrosinase related protein 1 | 5.2 | 2.68E-05 | Â |
DSP | Desmoplakin | 5.1 | 8.91E-05 | Â |
C3 | Complement C3 | 5.1 | 0.00067128 | Â |
SLPI | Secretory leukocyte peptidase inhibitor | 5.1 | 7.24E-05 | Â |