Table 2 Selected single-nucleotide polymorphisms in relation to vitamin D level and breast cancer
From: SNPs related to vitamin D and breast cancer risk: a case-control study
SNP (GWAS SNP) | Risk of low vitamin D | Risk of breast cancer | ||||
|---|---|---|---|---|---|---|
Allele | Frequency of low/high vitamin Da (n = 1343) | Crude OR of low vitamin D (95% CI) | Adjusted ORb of low vitamin D (95% CI) | Cases/control subjects (n = 4058) | Crude OR (95% CI) | Adjusted ORb (95% CI) |
rs12239582 (rs12144344) | ||||||
CC | 224/188 | 1.00 | 1.00 | 290/986 | 1.00 | 1.00 |
CA | 344/336 | 0.86 (0.67–1.10) | 0.87 (0.67–1.12) | 412/1604 | 0.87 (0.74–1.04) | 0.82 (0.68–0.99) |
AA | 116/135 | 0.72 (0.53–0.99) | 0.72 (0.52–1.00) | 163/600 | 0.92 (0.74–1.15) | 0.93 (0.73–1.17) |
Missing | – | – | – | 0/3 | – | – |
rs705117 | ||||||
CC | 504/486 | 1.00 | 1.00 | 657/2376 | 1.00 | 1.00 |
CT | 164/168 | 0.94 (0.73–1.21) | 0.94 (0.73–1.22) | 194/762 | 0.92 (0.77–1.10) | 0.86 (0.71–1.05) |
TT | 16/5 | 3.06 (1.11–8.44) | 3.38 (1.20–9.49) | 14/55 | 0.92 (0.51–1.67) | 0.94 (0.49–1.81) |
rs7041 | ||||||
AA | 213/270 | 1.00 | 1.00 | 332/1149 | 1.00 | 1.00 |
AC | 341/308 | 1.40 (1.11–1.78) | 1.39 (1.09–1.77) | 397/1521 | 0.90 (0.77–1.07) | 0.88 (0.74–1.05) |
CC | 130/81 | 2.03 (1.46–2.83) | 2.12 (1.51–2.99) | 136/522 | 0.90 (0.72–1.13) | 0.89 (0.70–1.13) |
Missing | – | – | – | 0/1 | – | – |
rs2282679 (rs17467825) | ||||||
GG | 342/397 | 1.00 | 1.00 | 480/1734 | 1.00 | 1.00 |
GT | 278/230 | 1.40 (1.12–1.76) | 1.42 (1.13–1.80) | 326/1222 | 0.96 (0.82–1.13) | 0.98 (0.83–1.16) |
TT | 62/29 | 2.45 (1.56–3.95) | 2.51 (1.56–4.05) | 57/229 | 0.90 (0.66–1.22) | 0.91 (0.66–1.27) |
Missing | 2/3 | – | – | 2/8 | – | – |
rs10485165 | ||||||
TT | 515/501 | 1.00 | 1.00 | 650/2385 | 1.00 | 1.00 |
TC | 153/144 | 1.04 (0.80–1.35) | 1.03 (0.79–1.34) | 194/735 | 0.97 (0.81–1.16) | 0.99 (0.82–1.20) |
CC | 16/14 | 1.10 (0.53–2.29) | 1.04 (0.49–2.21) | 21/73 | 1.06 (0.65–1.73) | 1.00 (0.60–1.74) |
rs198300 (rs156299) | ||||||
GG | 218/229 | 1.00 | 1.00 | 295/1134 | 1.00 | 1.00 |
GA | 344/319 | 1.13 (0.89–1.44) | 1.08 (0.84–1.38) | 430/1513 | 1.09 (0.92–1.29) | 1.10 (0.91–1.30) |
AA | 122/111 | 1.16 (0.84–1.59) | 1.09 (0.79–1.52) | 140/545 | 0.99 (0.79–1.24) | 0.96 (0.75–1.22) |
Missing | – | – | – | 0/1 | – | – |
rs4751058 | ||||||
AA | 496/460 | 1.00 | 1.00 | 614/2286 | 1.00 | 1.00 |
AG | 174/183 | 0.88 (0.69–1.13) | 0.88 (0.68–1.13) | 234/828 | 1.05 (0.89–1.25) | 1.05 (0.88–1.27) |
GG | 14/16 | 0.81 (0.39–1.68) | 0.77 (0.36–1.63) | 17/79 | 0.80 (0.47–1.36) | 0.66 (0.38–1.17) |
rs12295888 (rs12287212) | ||||||
CC | 270/296 | 1.00 | 1.00 | 367/1384 | 1.00 | 1.00 |
CT | 321/302 | 1.16 (0.93–1.46) | 1.22 (0.96–1.54) | 402/1435 | 1.06 (0.90–1.24) | 1.05 (0.88–1.24) |
TT | 93/61 | 1.67 (1.16–2.40) | 1.80 (1.24–2.63) | 96/373 | 0.97 (0.75–1.25) | 0.93 (0.71–1.23) |
Missing | – | – | – | 0/1 | – | – |
rs1007392 | ||||||
GG | 231/267 | 1.00 | 1.00 | 325/1184 | 1.00 | 1.00 |
GA | 337/310 | 1.26 (0.99–1.59) | 1.31 (1.03–1.67) | 417/1543 | 0.99 (0.84–1.16) | 0.99 (0.83–1.18) |
AA | 115/82 | 1.62 (1.16–2.26) | 1.78 (1.26–2.52) | 123/462 | 0.97 (0.77–1.23) | 0.91 (0.71–1.17) |
Missing | 1/0 | – | – | 0/4 | – | – |
rs2060793 (rs10741657) | ||||||
AA | 246/194 | 1.00 | 1.00 | 283/1040 | 1.00 | 1.00 |
AG | 328/323 | 0.80 (0.63–1.02) | 0.78 (0.61–1.00) | 418/1544 | 1.00 (0.84–1.18) | 1.10 (0.92–1.33) |
GG | 110/142 | 0.61 (0.45–0.84) | 0.58 (0.42–0.81) | 164/606 | 1.00 (0.80–1.24) | 1.04 (0.82–1.32) |
Missing | – | – | – | 0/3 | – | – |
rs7944926 (rs12785878) | ||||||
AA | 297/343 | 1.00 | 1.00 | 423/1436 | 1.00 | 1.00 |
AG | 299/272 | 1.27 (1.01–1.59) | 1.30 (1.03–1.64) | 366/1400 | 0.89 (0.76–1.04) | 0.91 (0.77–1.08) |
GG | 88/44 | 2.31 (1.56–3.43) | 2.39 (1.59–3.59) | 76/356 | 0.73 (0.55–0.95) | 0.77 (0.57–1.02) |
Missing | – | – | – | 0/1 | – | – |
rs3829251 | ||||||
AA | 402/435 | 1.00 | 1.00 | 545/1954 | 1.00 | 1.00 |
AG | 242/210 | 1.25 (0.99–1.57) | 1.30 (1.02–1.64) | 287/1079 | 0.95 (0.81–1.12) | 0.99 (0.83–1.18) |
GG | 40/14 | 3.09 (1.65–5.77) | 3.26 (1.72–6.17) | 33/160 | 0.74(0.50–1.09) | 0.77 (0.51–1.16) |
rs2302190 | ||||||
CC | 451/466 | 1.00 | 1.00 | 566/2122 | 1.00 | 1.00 |
CT | 211/176 | 1.24 (0.98–1.57) | 1.24 (0.97–1.58) | 268/955 | 1.05(0.89–1.24) | 1.09 (0.91–1.30) |
TT | 20/13 | 1.59 (0.78–3.23) | 1.45 (0.69–3.02) | 28/109 | 0.96 (0.63–1.47) | 0.99 (0.62–1.58) |
Missing | 2/4 | – | – | 3/7 | – | – |