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Fig. 5 | Breast Cancer Research

Fig. 5

From: Roles of BCCIP deficiency in mammary tumorigenesis

Fig. 5

Mammary tumor formation in p53–/– mice. a Overall survival of BCCIP-CON and BCCIP-CKD mice with concurrent homozygous and hemizygous p53 deletions. b Mammary tumor-free survival of BCCIP-CON and BCCIP-CKD mice with concurrent homozygous and hemizygous p53 deletions. c HE stains of formalin-fixed paraffin-embedded sections from mammary tumors on BCCIP-CKD;p53–/– females. Right panel shows a higher magnification from the highlighted area to show squamous cells within the tumors (yellow arrows). d IHC of breast cancer derived from BCCIP-CKD and p53–/– mice. Right panel shows a higher magnification of clusters of BCCIP positive cells (black arrows) within the mostly BCCIP negative tissue in the tumor specimens. CKD FVB:LoxPshBCCIP +/− ;K14-Cre +/−, CON FVB:LoxPshBCCIP +/− ;K14-Cre −/−

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