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Fig. 3 | Breast Cancer Research

Fig. 3

From: Roles of BCCIP deficiency in mammary tumorigenesis

Fig. 3

Formation of mammary nodules and overall survival of conditional BCCIP knockdown mice. a, b Gross appearance of representative mammary nodules. c Kaplan–Meier plots of mice surviving without formation of palpable benign nodule. d Kaplan–Meier plots of overall survival of BCCIP-CKD (red line) and BCCIP-Con (blue line) littermates. e Proliferated layers of duct epithelial cells (DEC) and the noncellular core (NCC) of the nodule. f Ki67 staining of a serial section from e. Arrow indicates the layer of Ki67 positive cells at the edge of the proliferative layers. g K14 staining of the serial section of e. Proliferated multiple layers of duct epithelial cells are K14 positive, and external layers of epithelial cells are proliferative (based on the Ki67 marker). DAPI 4′,6-diamidino-2-phenylindole, HE hematoxylin and eosin, CKD FVB:LoxPshBCCIP +/− ;K14-Cre +/−, CON FVB:LoxPshBCCIP +/− ;K14-Cre −/−

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