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Table 3 Protein targets significantly associated with recurrence-free survival (RFS)

From: Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors

Target HR 95% CI P value FDR Affiliation
SHMT2 1.88 1.50–2.36 <0.001 <0.001 Serine metabolism
ASCT2 1.83 1.45–2.31 <0.001 <0.001 Glutamine metabolism
GAPDH 1.52 1.19–1.94 <0.001 0.009 Glucose metabolism
FH 1.65 1.20–2.27 0.002 0.019 TCA cycle
CAD 2.07 1.29–3.33 0.003 0.019 Pyrimidine metabolism
PKM2 1.46 1.13–1.88 0.003 0.02 Glucose metabolism
  1. RFS events = 109
  2. HR hazard ratio, FDR false-discovery rate, CI confidence interval, SHMT2 serine hydroxymethyltransferase 2, ASCT2 ASC amino-acid transporter 2, GAPDH glyceraldehyde-3-phosphate dehydrogenase, TCA tricarboxylic acid, FH fumarate hydratase, CAD carbamoyl-phosphate synthetase 2, PKM2 pyruvate kinase 2