Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer

Table 7 Multivariate association between biomarkers and RDI < 85%

Biomarkers/Clinical factors	Odds ratio (95%CI)	P value
IL-6 or D-dimer combination^a
1 or 2 vs. 0	2.54 (1.03–6.23)	0.04
Age	1.06 (1.02–1.10)	<0.01
Physical function measured by MOS-ADL^b	0.98 (0.96–1.00)	0.04
Breast cancer stage
Stage II vs. I	0.66 (0.22–1.98)	0.46
Stage III vs. I	0.23 (0.05–0.97)	0.04
Anthracycline-containing regimen

^a IL-6 or D-dimer combination: 0 = both markers in lower three quartiles; 1 = 1or 2 of the markers in the 4^th quartile
^bMOS-ADL: Activities of Daily Living (subscale of MOS physical health)

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