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Fig. 6 | Breast Cancer Research

Fig. 6

From: Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

Fig. 6

In-vivo study of drug response using cells carrying ZNF423 WT (CRISPR-ZR75-1) or variant genotypes. a Tumors removed from the mice in each treatment group (eight mice) after 30 days of drug treatment. b Tumor volume measured every 3 days during treatment. Volume shown as mean ± SEM for eight mice, comparisons between WT and variant performed with two-tailed Student’s t test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Ola olaparib, PBS phosphate-buffered saline, Tam tamoxifen, WT wild type

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