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Table 3 Breast cancer risk associated with Breast Imaging Reporting and Data System breast density cross-classified with dense breast volume

From: Combining quantitative and qualitative breast density measures to assess breast cancer risk

Dense breast volume,b ml BI-RADS breast density aa BI-RADS breast density ba BI-RADS breast density ca BI-RADS breast density da Overall
OR (95% CI)c OR (95% CI)c OR (95% CI)c OR (95% CI)c OR (95% CI)c
Quartile 1: ≤ 35.9 0.63 (0.45–0.89) 0.94 (0.72–1.21) 1.03 (0.71–1.49) 1.53 (0.75–3.09) 0.85 (0.71–1.03)
Quartile 2: 36.0–50.0 0.60 (0.43–0.84) 1.00 (reference) 1.25 (0.92–1.69) 1.50 (0.82–2.73) 1.00 (reference)
Quartile 3: 50.1–70.0 0.70 (0.49–0.99) 0.98 (0.76–1.27) 1.43 (1.09–1.89) 2.87 (1.84–4.47) 1.19 (1.00–1.42)
Quartile 4: 70.1+ 0.87 (0.54–1.41) 1.15 (0.87–1.53) 1.67 (1.31–2.12) 2.56 (1.87–3.52) 1.62 (1.36–1.92)
  1. BI-RADS Breast Imaging Reporting and Data System
  2. aBI-RADS breast density: a = almost entirely fat, b = scattered fibroglandular densities, c = heterogeneously dense, d = extremely dense
  3. bMeasured with Volpara software
  4. cAdjusted for age, body mass index, family history of breast cancer, history of breast biopsy, and race/ethnicity. Statistically significant results are shown in boldface type