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Fig. 9 | Breast Cancer Research

Fig. 9

From: Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Fig. 9

a. Dual immunohistochemistry staining (red = vimentin, brown = E-cadherin) of CDH1-modified cell line xenografts. Original magnification × 40 and × 400. b Closer inspection of 468-shCDH1-B (top, hematoxylin and eosin [H&E] staining; bottom, dual E-cadherin and vimentin staining) with higher-magnification inset. Scale bar = 50 μm. c Two types of extratumoral local lymphovascular invasion observed in tumors. Invaded cells presented as tumor emboli composed of well-cohesive tumor cells (top panel, left), and more rarely seen invaded cells remained as scattered individual cells (top row, right). 468-shCDH1-B tumor emboli were smaller than the rest and composed of loosely adhered cells (middle row). Tumor cells were also observed within intratumoral blood vessels of 468-shCDH1-B tumors (bottom row). WT Wild type

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