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Table 2 Early pregnancy endogenous hormones and breast cancer risk: Northern Sweden Maternity Cohort

From: Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort

   Tertile p trend
1 2 3
Estradiol
 All women Cases/controls 68/137 70/134 82/133  
OR (95% CI) Reference 1.06 (0.69–1.63) 1.29 (0.80–2.07) 0.15
 ER+/PR+ Cases/controls 47/98 54/94 51/90  
OR (95% CI) Reference 1.16 (0.69–1.93) 1.11 (0.62–1.97) 0.60
Free estradiol
 All women Cases/controls 67/127 78/126 65/121  
OR (95% CI) Reference 1.14 (0.74–1.75) 0.95 (0.59–1.54) 0.86
 ER+/PR+ Cases/controls 48/90 54/83 41/85  
OR (95% CI) Reference 1.13 (0.68–1.90) 0.81 (0.45–1.44) 0.72
Estrone
 All women Cases/controls 63/138 81/137 78/135  
OR (95% CI) Reference 1.27 (0.85–1.91) 1.25 (0.79–1.97) 0.45
 ER+/PR+ Cases/controls 47/97 60/96 47/93  
OR (95% CI) Reference 1.25 (0.77–2.02) 0.96 (0.55–1.65) 0.79
Testosterone
 All women Cases/controls 30/137 77/136 84/134  
OR (95% CI) Reference 1.29 (0.84–1.96) 1.46 (0.96–2.21) 0.04
 ER+/PR+ Cases/controls 36/99 57/95 60/89  
OR (95% CI) Reference 1.69 (1.00–2.86) 1.94 (1.16–3.25) 0.01
Free testosterone
 All women Cases/controls 73/128 57/127 81/122  
OR (95% CI) Reference 0.81 (0.52–1.25) 1.16 (0.73–1.83) 0.47
 ER+/PR+ Cases/controls 44/97 41/79 59/84  
OR (95% CI) Reference 1.23 (0.72–2.12) 1.68 (0.96–2.94) 0.04
Progesterone
 All women Cases/controls 74/138 80/134 67/134  
OR (95% CI) Reference 1.10 (0.72–1.68) 0.89 (0.56–1.40) 0.77
 ER+/PR+ Cases/controls 55/84 55/99 43/99  
OR (95% CI) Reference 0.75 (0.44–1.27) 0.55 (0.31–0.99) 0.05
SHBG
 All women Cases/controls 59/128 67/127 86/129  
OR (95% CI) Reference 1.21 (0.78–1.87) 1.68 (1.05–2.70) 0.13
 ER+/PR+ Cases/controls 44/85 46/83 55/96  
OR (95% CI) Reference 1.08 (0.64–1.83) 1.18 (0.67–2.08) 0.70
  1. Conditional logistic regression controlling for gestational age at blood collection (continuous)
  2. CI confidence interval, ER estrogen receptor, OR odds ratio, PR progesterone receptor, SHBG sex hormone binding globulin