Fig. 6
From: Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis
Loss of ERβ is associated with occurrence of EMT in mammary tumors. Microphotographs of serial tumor sections analyzed by immunohistochemistry for the expression of E-cadherin, vimentin, α-SMA and the cytoplasmic active form of B-catenin. Areas of tumors arising in the absence of ERβ (K14CreERβ F/F p53 F/F mice) display decreased levels or loss of E-cadherin and increased expression of vimentin, α-SMA and B-catenin. Scale bars, 100 μm. ER estrogen receptor, α-SMA alpha-smooth muscle actin