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Fig. 4 | Breast Cancer Research

Fig. 4

From: miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer

Fig. 4

miR-629-3p promotes cell proliferation and invasion of triple-negative breast cancer (TNBC). a The relative expression levels of miR-629-3p in four highly metastatic TNBC cell lines were significantly higher than in non-TNBC cell lines. b 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay results showed that the viability of MDA-MB-231 cells was markedly suppressed by an inhibitor of miR-629-3p (anti-miR-629) compared with scrambled oligonucleotide 1 (Scr1). However, ectopic expression of miR-629-3p considerably increased the viability of MCF-7 cells compared with scrambled oligonucleotide 2 (Scr2). c and d Analysis of cellular migration and invasion using the wound-healing and transwell assays demonstrated that enforced upregulation of miR-629-3p significantly enhanced the migration and invasion capability of MCF-7 cells, whereas inhibition of miR-629-3p dramatically attenuated the migration and invasion capability of MDA-MB-231 cells. Representative images of the assays are shown in the right panel. Original magnification × 200. All data are presented as an average of triplicate measurements with SE. *P < 0.05 and ** P < 0.01

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