Table 1 Distributions in measures of terminal duct lobular unit involution by breast cancer risk factors and tumor characteristics among Chinese patients with breast cancer
Overall (n = 504) | Measures of TDLU involution | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Count/100 mm2 | Maximum span (μm) | Maximum category of acini count/TDLUa | ||||||||
Subjects (n) | % | Median | (IQR) | Median | (IQR) | 1–3 | 4–6 | |||
Number | % | Number | % | |||||||
Age | ||||||||||
All, mean (SD) | 50.4 | 9.4 | ||||||||
20–39 years | 48 | 9.5 | 30.8 | (15.7–48.0) | 924 | (759.5–1308.5) | 14 | 5.0 | 34 | 15.3 |
40–49 years | 204 | 40.5 | 29.9 | (17.4–44.6) | 934.5 | (712–1154) | 71 | 25.2 | 133 | 59.9 |
50–59 years | 176 | 34.9 | 12.3 | (7.0–22.9) | 674 | (532.5–847.5) | 131 | 46.5 | 45 | 20.3 |
60–79 years | 76 | 15.1 | 8.7 | (3.7–15.2) | 559 | (391.5–740) | 66 | 23.4 | 10 | 4.5 |
P valueb | <0.0001 | <0.0001 | <0.0001 | |||||||
Body mass index | ||||||||||
All, mean (SD) | 25.1 | 3.7 | ||||||||
< 23 kg/m2 | 155 | 30.9 | 19.2 | (8.7–32.6) | 773 | (599–1075) | 84 | 30.1 | 71 | 32.0 |
23–24.9 kg/m2 | 121 | 24.2 | 19.0 | (10.2–37.2) | 747 | (565–964) | 67 | 24.0 | 54 | 24.3 |
25–29.9 kg/m2 | 180 | 35.9 | 18.8 | (9.1–36.8) | 813.5 | (613–1025) | 98 | 35.1 | 82 | 36.9 |
30+ kg/m2 | 45 | 9.0 | 14.3 | (8.3–27.2) | 784 | (566–946) | 30 | 10.8 | 15 | 6.8 |
P valueb | 0.73 | 0.50 | 0.92 | |||||||
Family history of breast cancer | ||||||||||
No | 470 | 95.0 | 18.3 | (8.7–34.8) | 775 | (591–1023) | 265 | 95.0 | 205 | 94.9 |
Yes | 25 | 5.1 | 17.1 | (10.7–30.0) | 751 | (461–979) | 14 | 5.0 | 11 | 5.1 |
P valueb | 0.76 | 0.12 | 0.55 | |||||||
Age at menarche | ||||||||||
< 12 years | 122 | 25.4 | 18.9 | (10.8–38.6) | 789.5 | (603–1023) | 68 | 24.7 | 54 | 26.2 |
12–13 years | 215 | 44.7 | 19.7 | (8.5–36.3) | 796 | (611–1080) | 112 | 40.7 | 103 | 50.0 |
14+ years | 144 | 29.9 | 15.4 | (7.2–28.6) | 713 | (536.5–954) | 95 | 34.6 | 49 | 23.8 |
P valueb | 0.99 | 0.99 | 0.94 | |||||||
Parity/number of children | ||||||||||
Nulliparous | 18 | 3.9 | 10.9 | (4.6–36.6) | 818 | (482–1155) | 11 | 4.2 | 7 | 3.4 |
One child | 290 | 62.1 | 20.0 | (11.1–36.3) | 804.5 | (612–1075) | 147 | 56.3 | 143 | 69.4 |
More than one child | 159 | 34.1 | 14.7 | (7.3–33.8) | 754 | (547–955) | 103 | 39.5 | 56 | 27.2 |
P valueb | 0.02 | 0.14 | 0.06 | |||||||
Breastfeedingc | ||||||||||
No | 19 | 6.2 | 15.4 | (7.8–28.1) | 565 | (468–887) | 14 | 8.1 | 5 | 3.8 |
Yes | 286 | 93.8 | 18.3 | (9.0–34.2) | 790.5 | (621–1025) | 158 | 91.9 | 128 | 96.2 |
P valueb | 0.48 | 0.05 | 0.08 | |||||||
Tumor subtype | ||||||||||
Luminal A | 254 | 50.4 | 17.4 | (8.3–32.8) | 764.5 | (600–992) | 152 | 53.9 | 102 | 46.0 |
Triple-negative/core basal phenotype | 250 | 49.6 | 19.5 | (10.0–37.8) | 803 | (588–1043) | 130 | 46.1 | 120 | 54.1 |
P valueb | 0.45 | 0.10 | 0.03 | |||||||
Tumor size | ||||||||||
≤ 2 cm | 277 | 56.4 | 18.3 | (8.3–34.2) | 777 | (583–998) | 160 | 58.4 | 117 | 53.9 |
> 2 cm | 214 | 43.6 | 20.0 | (10.1–35.8) | 794 | (606–1034) | 114 | 41.6 | 100 | 46.1 |
P valueb | 0.71 | 0.76 | 0.19 | |||||||
Lymph node invasion | ||||||||||
Negative | 286 | 58.7 | 17.6 | (9.4–34.9) | 780.5 | (566–989) | 160 | 58.6 | 126 | 58.9 |
Positive | 201 | 41.3 | 19.8 | (8.4–34.1) | 781 | (604–1075) | 113 | 41.4 | 88 | 41.1 |
P valueb | 0.86 | 0.27 | 0.81 | |||||||
Grade | ||||||||||
Well differentiated | 47 | 10.2 | 20.3 | (8.3–40.0) | 887 | (644–1198) | 26 | 10.0 | 21 | 10.5 |
Moderately differentiated | 201 | 43.5 | 17.5 | (9.4–36.0) | 770 | (599–979) | 113 | 43.3 | 88 | 43.8 |
Poorly differentiated | 214 | 46.3 | 18.7 | (9.2–33.0) | 774.5 | (566–1025) | 122 | 46.7 | 92 | 45.8 |
P valueb | 0.32 | 0.01 | 0.07 | |||||||