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Table 4 The associations of weight and height with pubertal outcomes, by breast cancer family history (BCFH)

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

  Odds ratio (95% confidence interval)
Overall BCFH+ girls BCFH– girls
Breast Tanner stage T2 + a
 n 786 383 403
 Model 1c
 Weight (per 1 kg) 1.09 (1.05–1.12) 1.06 (1.03–1.10) 1.14 (1.04–1.24)
 Height (per 1 cm) 1.03 (0.99–1.07) 1.03 (0.99–1.08) 1.01 (0.94–1.09)
 Race/ethnicity
  Non-Hispanic white 1.00 (reference) 1.00 (reference) 1.00 (reference)
  Asian 0.55 (0.22–1.41) 0.66 (0.18–2.37) 0.55 (0.16–1.86)
  Black 3.88 (1.74–8.65) 5.04 (1.21–20.94) 3.80 (1.43–10.11)
  Hispanic 1.18 (0.65–2.13) 1.34 (0.58–3.14) 0.91 (0.37–2.25)
  Mixed race/ethnicity 2.54 (0.75–8.54) 7.61 (0.11–533.98) 1.81 (0.56–5.78)
 Model 2d
 Overweight (≥85th percentile) 4.65 (2.58–8.38) 3.32 (1.43–7.69) 6.72 (2.70–16.74)
Pubic hair Tanner stage T2 + a
 n 819 403 416
 Model 1c
 Weight (per 1 kg) 1.02 (0.99–1.05) 1.02 (0.98–1.06) 1.02 (0.98–1.06)
 Height (per 1 cm) 1.06 (1.03–1.10) 1.05 (1.00–1.11) 1.07 (1.02–1.12)
 Race/ethnicity
   Non-Hispanic white 1.00 (reference) 1.00 (reference) 1.00 (reference)
   Asian 0.44 (0.21–0.95) 0.39 (0.13–1.20) 0.46 (0.17–1.24)
   Black 5.27 (2.38–11.65) 9.58 (2.53–36.19) 3.88 (1.48–10.17)
   Hispanic 1.55 (0.85–2.84) 1.71 (0.65–4.47) 1.36 (0.60–3.11)
   Mixed race/ethnicity 1.46 (0.37–5.77) 2.45 (0.54–11.05) 1.09 (0.16–7.53)
 Model 2d
 Overweight (≥85th percentile) 1.24 (0.75–2.06) 1.26 (0.56–2.83) 1.40 (0.71–2.75)
Post-menarche statusb
 n 493 260 233
 Model 1c
 Weight (per 1 kg) 1.08 (1.04–1.12) 1.09 (1.03–1.16) 1.06 (1.00–1.12)
 Height (per 1 cm) 1.03 (0.99–1.08) 0.98 (0.93–1.05) 1.09 (1.03–1.16)
 Race/ethnicity
   Non-Hispanic white 1.00 (reference) 1.00 (reference) 1.00 (reference)
   Asian 1.06 (0.46–2.45) 0.52 (0.15–1.81) 1.60 (0.46–5.58)
   Black 1.69 (0.65–4.40) 1.37 (0.34–5.51) 2.07 (0.50–8.54)
   Hispanic 2.41 (1.15–5.04) 1.22 (0.49–3.09) 8.08 (2.24–29.19)
   Mixed race/ethnicity 2.21 (0.20–23.96) 0.29 (0.02–3.51) 5.28 (0.06–480.69)
 Model 2d
 Overweight (≥85th percentile) 4.19 (2.15–8.14) 4.75 (2.08–10.82) 3.73 (1.21–11.51)
  1. aExcludes girls aged ≥13 years (n = 135)
  2. bExcludes girls aged <10 years (n = 510)
  3. cModel includes weight, height, race/ethnicity, and is adjusted for age and study site. Non-Hispanic white is the referent race/ethnicity
  4. dModel includes overweight and is adjusted for height, race/ethnicity, age, and study site. Non-Hispanic white is the referent race/ethnicity