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Fig. 8 | Breast Cancer Research

Fig. 8

From: Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

Fig. 8

A schematic diagram illustrating the use of 3D pathomimetic mammary architecture and microenvironment engineering (MAME) cultures to identify a divergent interplay between tumor-suppressive myoepithelial cells (MEPs) and tumor-promoting cancer-associated fibroblasts (CAFs) that involves plasminogen activator inhibitor 1 (PAI-1), urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR), and interleukin 6 (IL-6) and alters the cellular and molecular phenotype of ductal carcinoma in situ (DCIS). ECM Extracellular matrix, rBM Reconstituted basement membrane

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Breast Cancer Research

ISSN: 1465-542X

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