Fig. 3

a, c, e Feature expression maps for top radiomic features. b, d, f Corresponding hematoxylin and eosin-stained images at × 100 original magnification taken from the original diagnostic core biopsy specimen before neoadjuvant chemotherapy. All-comers: a Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) information measure of correlation 1 is elevated in pathological complete response (pCR) tumors intratumorally during the initial postcontrast phase. b For a patient who experienced pCR, the corresponding histology shows a high percentage of stromal tumor-infiltrating lymphocytes (TILs) present relatively uniformly within the invasive carcinoma. The histopathological image from the non-pCR patient on the right shows a heterogeneous mix of tumor cells, necrosis, and sclerosis. HR ⁺ /HER2 ⁻ : c Peritumoral initial CoLlAGe entropy is increased among HR⁺, HER2⁻ nonresponders. d Corresponding histology for peritumoral regions of HR⁺/HER2⁻ patients with and without a pCR. The image on the left shows a brisk lymphocytic response at the periphery of the tumor. The image on the right from the non-pCR patient shows tumor cells infiltrating the adipose tissue at the periphery of the lesion without a significant stromal response. TN/HER2 ⁺ : e Peritumoral peak Laws level-ripple is elevated in non-pCR tumors. f Peritumoral regions from patients with TN breast cancer with and without a pCR. Once again, there is a brisk lymphocytic response in the peritumoral region and numerous stromal TILs within the tumor on the left. The image of the non-pCR on the right is from a patient with TN breast cancer with a matrix-producing metaplastic carcinoma. The tumor cells with associated chondroid matrix are dissecting through the adipose tissue at the periphery of the lesion. HER2 Human epidermal growth factor receptor 2, HR Hormone receptor, TN Triple-negative