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Table 1 Characteristics of DMBA-induced tumours from control and Mmtv-Ccl2 mice

From: CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

Genotype Latency (weeks) Histopathology Mitotic index Inflammation
Control 13 Spindeloid carcinoma 0 2
  10 Adenosqaumous carcinoma 3 5
  14 Adenosqaumous carcinoma 2 2
  16 Early MIN 0 0
  10 Adenosquamous carcinoma N/A 4
  12 Adenosquamous carcinoma 1 4
  11 Carcinosarcoma 0 2
  10 Early MIN 0 1
Mmtv-Ccl2 10 Acinar 0 0
  11 Adenosquamous carcinoma N/A 2
  10 Adenosquamous carcinoma 2 5
  19 Early MIN 0 0
  10 Adenosqaumous carcinoma 0 2
  13 Glandular carcinoma 0 2
  13 Cribiform carcinoma 1 4
  8 Adenosquamous carcinoma 1 5
  19 Early MIN 0 0
  1. Latency in weeks after final 7,12-Dimethylbenz(a)anthracene (DMBA) administration. Mitotic index was determined by counting the number of mitotic cells in a × 10 field of view. Inflammation was scored as 0 (none), 1 (mild, focal), 2 (mild, multifocal), 3 (moderate, focal), 4 (moderate, multifocal) or 5 (marked, diffuse or multifocal). MIN mammary intraepithelial neoplasia, N/A not assessed