Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

Breast Cancer Research

Table 4 Best fitting models describing the association between life-course body size and estrogen-receptor-positive postmenopausal breast cancer risk, by HT use

Height	BMI (age 18 years)	BMI (baseline)	Weight change (age 18 years to baseline)	Adiposity	Cases	HR	95% CI
Current HT use
Short					887	1.0^b
Tall		Normal			190	1.11	0.95–1.30
Tall		Overweight/obese			130	1.36	1.13–1.64
Not using HT
Short	Normal	Normal	<10 lbs		83	1.0^c
		Normal	≥10 lbs		115	1.36	1.03–1.81
		Overweight/obese		Abdominal	125	1.45	1.10–1.92
		Overweight/obese		Gluteal	30	2.70	1.77–4.10
	Overweight/obese	Normal			36	2.57	1.74–3.81
	Overweight/obese	Overweight/obese			24	1.33	0.84–2.10
Tall	Normal		<10 lbs		95	1.35	1.00–1.81
	Normal		≥10 lbs		384	1.77	1.40–2.25
	Overweight/obese				54	1.49	1.06–2.10

Body size cut-points: height <65, ≥65 (for postmenopausal women not using hormone therapy (HT)) and <67, ≥67 (for postmenopausal women currently using HT); body mass index (BMI) (age 18 years) <25, ≥25; BMI (baseline) <25, ≥25; adiposity ≥0.50 (abdominal), <0.50 (gluteal). ^aAdjusted for history of benign breast disease and family history of breast cancer in a first-degree relative; age was the time metric and the model was stratified by age at baseline. ^bAdjusted for nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, average alcohol consumption in the year prior to baseline, and neighborhood socioeconomic status; age was the time metric and the model was stratified by age at baseline. ^cAdjusted for age at menarche, nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, and consumption of a plant-based diet; age was the time metric and the model was stratified by age at baseline

ISSN: 1465-542X