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Table 4 Best fitting models describing the association between life-course body size and estrogen-receptor-positive postmenopausal breast cancer risk, by HT use

From: Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

Height BMI (age 18 years) BMI (baseline) Weight change (age 18 years to baseline) Adiposity Cases HR 95% CI
Current HT use
Short      887 1.0b  
Tall   Normal    190 1.11 0.95–1.30
  Overweight/obese    130 1.36 1.13–1.64
Not using HT
Short Normal Normal <10 lbs   83 1.0c  
≥10 lbs   115 1.36 1.03–1.81
Overweight/obese   Abdominal 125 1.45 1.10–1.92
  Gluteal 30 2.70 1.77–4.10
Overweight/obese Normal    36 2.57 1.74–3.81
Overweight/obese    24 1.33 0.84–2.10
Tall Normal   <10 lbs   95 1.35 1.00–1.81
≥10 lbs   384 1.77 1.40–2.25
Overweight/obese     54 1.49 1.06–2.10
  1. Body size cut-points: height <65, ≥65 (for postmenopausal women not using hormone therapy (HT)) and <67, ≥67 (for postmenopausal women currently using HT); body mass index (BMI) (age 18 years) <25, ≥25; BMI (baseline) <25, ≥25; adiposity ≥0.50 (abdominal), <0.50 (gluteal). aAdjusted for history of benign breast disease and family history of breast cancer in a first-degree relative; age was the time metric and the model was stratified by age at baseline. bAdjusted for nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, average alcohol consumption in the year prior to baseline, and neighborhood socioeconomic status; age was the time metric and the model was stratified by age at baseline. cAdjusted for age at menarche, nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, and consumption of a plant-based diet; age was the time metric and the model was stratified by age at baseline