Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

Horn-Ross, Pamela L.; Canchola, Alison J.; Bernstein, Leslie; Neuhausen, Susan L.; Nelson, David O.; Reynolds, Peggy

doi:10.1186/s13058-016-0790-5

Breast Cancer Research

Table 3 Full models reflecting body size over the life-course and estrogen-receptor-positive breast cancer risk, by menopausal status and HT use

From: Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

					Premenopaual			Postmenopausal, current HT use			Postmenopausal, not using HT
Height	BMI (age 18 years)	BMI (baseline)	Weight change (age 18 years to baseline)	Adiposity	Cases	HR^a	95% CI	Cases	HR^b	95% CI	Cases	HR^c	95% CI
Short	Normal	Normal	Loss		23	1.0		54	1.21	0.89–1.64	18	1.10	0.65 – 1.86
			Stable		23	1.0		172	1.0		65	1.0
			Gain		6	1.19	0.48 – 2.93	251	1.01	0.83–1.22	115	1.39	1.02 – 1.88
		Overweight/obese		Abdominal	5	2.47	0.94 – 6.53	127	1.15	0.92 – 1.45	125	1.48	1.10 – 2.00
				Gluteal	1	1.88	0.25 – 13.94	110	1.01	0.80 – 1.29	30	2.75	1.78 – 4.25
	Overweight/obese	Normal			39	0.87	0.52 – 1.45	35	1.03	0.71 – 1.48	36	2.63	1.75 – 3.95
		Overweight/obese		Abdominal	13	0.84	0.43 – 1.66	14	0.83	0.48 – 1.43	16	1.34	0.77 – 2.32
				Gluteal	4	1.09	0.38 – 3.15	7	0.83	0.39 – 1.77	1	1.46	0.20 – 10.56
Tall	Normal	Normal	Loss		40	1.21	0.73 – 2.03	19	1.22	0.76 – 1.97	25	1.42	0.90 – 2.26
			Stable		40	1.21	0.73 – 2.03	38	0.96	0.67 – 1.36	70	1.36	0.97 – 1.91
			Gain		18	2.02	1.09 – 3.75	117	1.22	0.96 – 1.54	159	1.66	1.24 – 2.21
		Overweight/obese		Abdominal	3	1.07	0.32 – 3.59	39	1.69	1.19 – 2.39	147	2.04	1.52 – 2.73
				Gluteal	2	1.44	0.34 – 6.14	52	1.41	1.03 – 1.92	33	2.09	1.37 – 3.18
	Overweight/obese	Normal			42	0.86	0.52 – 1.43	13	1.12	0.64 – 1.97	22	1.45	0.89 – 2.35
		Overweight/obese		Abdominal	11	0.62	0.30 – 1.28	5	1.06	0.43 – 2.58	20	1.65	1.00 – 2.72
				Gluteal	6	0.91	0.37 – 2.23	2	0.80	0.20 – 3.21	3	1.85	0.58 – 5.90

Body size cut-points: height <65, ≥65 (for premenopausal women and postmenopausal women not using hormone therapy (HT)) and <67, ≥67 (for postmenopausal women currently using HT); Body mass index (BMI) (age 18 years) <20, ≥20 (for premenopausal women) and <25, ≥25 (for postmenopausal women); BMI (baseline) <25, ≥25; weight change loss or gain <25 lbs (stable), gain ≥25 lbs (for premenopausal women) and loss ≥10 lbs (loss), loss <10 lbs or gain <10 lbs (stable), gain ≥10 lbs (for postmenopausal women); adiposity ≥0.50 (abdominal), <0.50 (gluteal) (for premenopausal women and postmenopausal women not using HT) and ≥0.56 (abdominal), <0.56 (gluteal) (for postmenopausal women currently using HT). ^aAdjusted for history of benign breast disease and family history of breast cancer in a first-degree relative; age was the time metric and the model was stratified by age at baseline. ^bAdjusted for nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, average alcohol consumption in the year prior to baseline, and neighborhood socioeconomic status; age was the time metric and the model was stratified by age at baseline. ^cAdjusted for age at menarche, nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, and consumption of a plant-based diet; age was the time metric and the model was stratified by age at baseline

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ISSN: 1465-542X

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