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Table 3 Full models reflecting body size over the life-course and estrogen-receptor-positive breast cancer risk, by menopausal status and HT use

From: Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort

  Premenopaual Postmenopausal, current HT use   Postmenopausal, not using HT
Height BMI (age 18 years) BMI (baseline) Weight change (age 18 years to baseline) Adiposity Cases HRa 95% CI Cases HRb 95% CI Cases HRc 95% CI
Short Normal Normal Loss   23 1.0   54 1.21 0.89–1.64 18 1.10 0.65 – 1.86
   Stable 172 1.0   65 1.0  
  Gain 6 1.19 0.48 – 2.93 251 1.01 0.83–1.22 115 1.39 1.02 – 1.88
  Overweight/obese   Abdominal 5 2.47 0.94 – 6.53 127 1.15 0.92 – 1.45 125 1.48 1.10 – 2.00
   Gluteal 1 1.88 0.25 – 13.94 110 1.01 0.80 – 1.29 30 2.75 1.78 – 4.25
Overweight/obese Normal    39 0.87 0.52 – 1.45 35 1.03 0.71 – 1.48 36 2.63 1.75 – 3.95
  Overweight/obese   Abdominal 13 0.84 0.43 – 1.66 14 0.83 0.48 – 1.43 16 1.34 0.77 – 2.32
   Gluteal 4 1.09 0.38 – 3.15 7 0.83 0.39 – 1.77 1 1.46 0.20 – 10.56
Tall Normal Normal Loss   40 1.21 0.73 – 2.03 19 1.22 0.76 – 1.97 25 1.42 0.90 – 2.26
   Stable   38 0.96 0.67 – 1.36 70 1.36 0.97 – 1.91
Gain   18 2.02 1.09 – 3.75 117 1.22 0.96 – 1.54 159 1.66 1.24 – 2.21
  Overweight/obese   Abdominal 3 1.07 0.32 – 3.59 39 1.69 1.19 – 2.39 147 2.04 1.52 – 2.73
   Gluteal 2 1.44 0.34 – 6.14 52 1.41 1.03 – 1.92 33 2.09 1.37 – 3.18
Overweight/obese Normal    42 0.86 0.52 – 1.43 13 1.12 0.64 – 1.97 22 1.45 0.89 – 2.35
  Overweight/obese   Abdominal 11 0.62 0.30 – 1.28 5 1.06 0.43 – 2.58 20 1.65 1.00 – 2.72
  Gluteal 6 0.91 0.37 – 2.23 2 0.80 0.20 – 3.21 3 1.85 0.58 – 5.90
  1. Body size cut-points: height <65, ≥65 (for premenopausal women and postmenopausal women not using hormone therapy (HT)) and <67, ≥67 (for postmenopausal women currently using HT); Body mass index (BMI) (age 18 years) <20, ≥20 (for premenopausal women) and <25, ≥25 (for postmenopausal women); BMI (baseline) <25, ≥25; weight change loss or gain <25 lbs (stable), gain ≥25 lbs (for premenopausal women) and loss ≥10 lbs (loss), loss <10 lbs or gain <10 lbs (stable), gain ≥10 lbs (for postmenopausal women); adiposity ≥0.50 (abdominal), <0.50 (gluteal) (for premenopausal women and postmenopausal women not using HT) and ≥0.56 (abdominal), <0.56 (gluteal) (for postmenopausal women currently using HT). aAdjusted for history of benign breast disease and family history of breast cancer in a first-degree relative; age was the time metric and the model was stratified by age at baseline. bAdjusted for nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, average alcohol consumption in the year prior to baseline, and neighborhood socioeconomic status; age was the time metric and the model was stratified by age at baseline. cAdjusted for age at menarche, nulliparity and age at first full-term pregnancy, history of benign breast disease, family history of breast cancer in a first-degree relative, and consumption of a plant-based diet; age was the time metric and the model was stratified by age at baseline