Table 1 Theoretically predicted OR and observed OR (95% CI) by the PRS percentiles

0–1

0.37

0.39 (0.27–0.57)

0–10

0.52

0.55 (0.49–0.61)

10–20

0.67

0.71 (0.64–0.79)

20–30

0.77

0.74 (0.66–0.82)

30–40

0.86

0.88 (0.80–0.98)

40–60

1.00, reference

1.00, reference

60–70

1.16

1.10 (0.99–1.21)

70–80

1.29

1.24 (1.13–1.37)

80–90

1.49

1.52 (1.38–1.67)

90–100

1.97

1.93 (1.76–2.12)

99–100

2.77

2.70 (2.15–3.40)

OR per decile of PRS

1.13 (1.12–1.14)

SD^a

0.38

c-statistics for PRS^b

0.602

c-statistic improvement^b

0.0386 (0.0259–0.0513)