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Table 1 Theoretically predicted OR and observed OR (95% CI) by the PRS percentiles

From: Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

PRS (%) Predicted ORa Observed OR (95% CI)
0–1 0.37 0.39 (0.27–0.57)
0–10 0.52 0.55 (0.49–0.61)
10–20 0.67 0.71 (0.64–0.79)
20–30 0.77 0.74 (0.66–0.82)
30–40 0.86 0.88 (0.80–0.98)
40–60 1.00, reference 1.00, reference
60–70 1.16 1.10 (0.99–1.21)
70–80 1.29 1.24 (1.13–1.37)
80–90 1.49 1.52 (1.38–1.67)
90–100 1.97 1.93 (1.76–2.12)
99–100 2.77 2.70 (2.15–3.40)
OR per decile of PRS   1.13 (1.12–1.14)
SDa 0.38  
c-statistics for PRSb   0.602
c-statistic improvementb   0.0386 (0.0259–0.0513)
  1. aPredicted ORs were estimated based on the PRS distribution with the SD 0.38
  2. bThe c-statistics and the improvement of c-statistics due to the PRS over the traditional risk factors (including age at menarche, age at first live birth, waist-to-hip ratio, breast cancer family history, and prior benign breast disease [21]) were estimated from the Shanghai breast cancer Genome-Wide Association Study
  3. CI confidence interval, OR odds ratio, PRS polygenic risk score, SD standard deviation