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Fig. 3 | Breast Cancer Research

Fig. 3

From: Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities

Fig. 3

Gene-based rare-variant association for overall breast cancer by distance from index genome-wide association study (GWAS) single-nucleotide polymorphism (SNP). y-Axis displays log10 gene association p values. Horizontal red line represents alpha = 0.05. Only the lower of two p values is plotted. For round points, the sequence kernel association test had the lower p value, and for square points, the burden test had a lower p value. Points are color-coded for the 12 breast cancer GWAS-identified index SNPs on 9 chromosomes. Region legend: 2 = TERT, 3 = MAP3K1, 4 = ESR1, 5 = 8q24, 6 = ZNF365, 7 = ZMIZ1, 8 = FGFR2, 9 = 11q13, 10 = RAD51B, 11 = TOX3 and 12 = 19p13

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