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Table 4 Ovarian tumor characteristics of BRCA1, BRCA2, and transheterozygote BRCA1 + BRCA2 mutation carriers

From: Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women

Trait Value BRCA1 + BRCA2 (TH)N(%) BRCA1 (SH1)N(%) P value BRCA1 + BRCA2 (TH)N(%) BRCA2 (SH2)N(%) P value
N   17 1550   15 314  
Grade Well differentiated 0 8 (2.8) 0.930 0 4 (6.2) 0.847
Moderately differentiated 1 (25) 60 (20.8)   1 (25) 12 (18.5)  
Poorly/undifferentiated 3 (75) 220 (76.4)   3 (75) 49 (75.4)  
Stage 1 0 39 (17.4) 0.600 0 6 (13.3) 0.589
2 1 (33.3) 31 (13.8)   1 (33.3) 5 (11.1)  
3 2 (66.7) 120 (53.6)   2 (66.7) 28 (62.2)  
4 0 34 (15.2)   0 6 (13.3)  
Morphology Serous 5 (83.3) 292 (66.8) 0.905 5 (83.3) 71 (73.2) 0.943
Mucinous 0 4 (0.9)   0 2 (2.0)  
Endometroid 0 44 (10.1)   0 7 (7.2)  
Clear cell 0 6 (1.4)   0 2 (2.0)  
Other 1 (16.7) 91 (20.8)   1 (16.7) 15 (15.5)  
Behavior Invasive 7 (100) 449 (99.1) 0.803 6 (100) 89 (95.7) 0.604
Borderline 0 4 (0.9)   0 4 (4.3)