Table 4 Ovarian tumor characteristics of BRCA1, BRCA2, and transheterozygote BRCA1 + BRCA2 mutation carriers
Trait | Value | BRCA1 + BRCA2 (TH)N(%) | BRCA1 (SH1)N(%) | P value | BRCA1 + BRCA2 (TH)N(%) | BRCA2 (SH2)N(%) | P value |
|---|---|---|---|---|---|---|---|
N | 17 | 1550 | 15 | 314 | |||
Grade | Well differentiated | 0 | 8 (2.8) | 0.930 | 0 | 4 (6.2) | 0.847 |
Moderately differentiated | 1 (25) | 60 (20.8) | 1 (25) | 12 (18.5) | |||
Poorly/undifferentiated | 3 (75) | 220 (76.4) | 3 (75) | 49 (75.4) | |||
Stage | 1 | 0 | 39 (17.4) | 0.600 | 0 | 6 (13.3) | 0.589 |
2 | 1 (33.3) | 31 (13.8) | 1 (33.3) | 5 (11.1) | |||
3 | 2 (66.7) | 120 (53.6) | 2 (66.7) | 28 (62.2) | |||
4 | 0 | 34 (15.2) | 0 | 6 (13.3) | |||
Morphology | Serous | 5 (83.3) | 292 (66.8) | 0.905 | 5 (83.3) | 71 (73.2) | 0.943 |
Mucinous | 0 | 4 (0.9) | 0 | 2 (2.0) | |||
Endometroid | 0 | 44 (10.1) | 0 | 7 (7.2) | |||
Clear cell | 0 | 6 (1.4) | 0 | 2 (2.0) | |||
Other | 1 (16.7) | 91 (20.8) | 1 (16.7) | 15 (15.5) | |||
Behavior | Invasive | 7 (100) | 449 (99.1) | 0.803 | 6 (100) | 89 (95.7) | 0.604 |
Borderline | 0 | 4 (0.9) | 0 | 4 (4.3) |