Table 3 Breast tumor characteristics of BRCA1, BRCA2, and transheterozygote BRCA1 + BRCA2 mutation carriers
Trait | Value | BRCA1 + BRCA2 (TH) N(%) | BRCA1 (SH1) N(%) | P value | BRCA1 + BRCA2 (TH) N(%) | BRCA2 (SH2) N(%) | P value |
|---|---|---|---|---|---|---|---|
N | 62 | 4846 | 60 | 1699 | |||
HER2 | Negative | 14 (93.3) | 908 (88.7) | 1.00 | 15 (93.8) | 274 (86.2) | 0.706 |
Positive | 1 (7.7) | 116 (11.3) | 1 (6.3) | 44 (13.8) | |||
PR | Negative | 19 (59.4) | 1260 (80.0) | 0.013 | 19 (59.4) | 215 (37.2) | 0.012 |
Positive | 13 (40.6) | 356 (20.0) | 13 (40.6) | 363 (62.8) | |||
ER | Negative | 20 (57.1) | 1347 (76.0) | 0.010 | 20 (57.1) | 150 (23.5) | <0.0001 |
Positive | 15 (42.9) | 424 (24.0) | 15 (42.9) | 487 (76.5) | |||
Nodal status | Negative | 20 (66.7) | 1197 (65.1) | 0.854 | 19 (65.5) | 399 (61.3) | 0.647 |
Positive | 10 (33.3) | 643 (35.0) | 10 (34.5) | 252 (38.7) | |||
Grade | Well differentiated | 2 (7.1) | 36 (2.3) | 0.161 | 2 (7.1) | 36 (6.4) | 0.690 |
Moderately differentiated | 8 (28.8) | 342 (22.1) | 8 (28.8) | 207 (36.6) | |||
Poorly/undifferentiated | 18 (64.3) | 1172 (75.6) | 18 (64.3) | 322 (57.0) | |||
Stage | 0 | 1 (4.8) | 34 (3.6) | 0.541 | 1 (4.6) | 48 (13.9) | 0.065 |
1 | 7 (33.3) | 399 (42.2) | 7 (31.8) | 123 (35.7) | |||
2 | 13 (61.9) | 440 (46.6) | 14 (63.6) | 124 (35.9) | |||
3 | 0 (0) | 65 (6.9) | 0 (0) | 36 (10.4) | |||
4 | 0 (0) | 7 (0.7) | 0 (0) | 14 (4.1) | |||
Morphology | Ductal | 26 (70.3) | 1544 (74.3) | 0.345 | 27 (73.0) | 629 (78.8) | 0.359 |
Lobular | 3 (8.1) | 61 (2.9) | 3 (8.1) | 70 (8.8) | |||
Medullary | 3 (8.1) | 173 (8.3) | 2 (5.4) | 13 (1.6) | |||
Other | 5 (13.5) | 301 (14.5) | 5 (13.5) | 86 (10.8) | |||
Number of positive nodes (SD) | 2 (6.1) | 1.2 (3.4) | 0.215 | 2.1 (6.2) | 1.7 (3.9) | 0.627 | |
Tumor size (SD) | 19.0 (14.9) | 18.3 (12.5) | 0.775 | 19.0 (14.9) | 19.2 (14.6) | 0.932 |