Table 1 Tumor characteristics of the BCAC study subjects
Non-carriers | p.I157T carriers | c.1100delC carriers | p value (I157T/nc) | p value (I157T/1100delC) | p value (1100delC/nc) | ||
|---|---|---|---|---|---|---|---|
ER | Negative | 4595 | 85 | 26 | 0.00046 | 0.61 | 0.0015 |
20.2 % | 15.5 % | 11.2 % | |||||
Positive | 18,179 | 462 | 207 | ||||
79.8 % | 84.5 % | 88.8 % | |||||
Missing | 3166 | 43 | 38 | ||||
12.2 % | 7.3 % | 14.0 % | |||||
PR | Negative | 6397 | 147 | 44 | 0.0034 | 0.90 | 0.0045 |
32.7 % | 28.5 % | 23.3 % | |||||
Positive | 13,173 | 368 | 145 | ||||
67.3 % | 71.5 % | 76.7 % | |||||
Missing | 6370 | 75 | 82 | ||||
24.6 % | 12.7 % | 30.3 % | |||||
Her2 | Negative | 8220 | 231 | 95 | 0.68 | 0.10 | 0.24 |
84.7 % | 83.7 % | 81.9 % | |||||
Positive | 1483 | 45 | 21 | ||||
15.3 % | 16.3 % | 18.1 % | |||||
Missing | 16,237 | 314 | 155 | ||||
62.6 % | 53.2 % | 57.2 % | |||||
EGFR | Negative | 3841 | 122 | 62 | 0.21 | 0.26 | 0.034 |
89.6 % | 90.4 % | 96.9 % | |||||
Positive | 448 | 13 | 2 | ||||
10.4 % | 9.6 % | 3.1 % | |||||
Missing | 21,651 | 455 | 207 | ||||
83.5 % | 77.1 % | 76.4 % | |||||
CK5/6 | Negative | 4734 | 143 | 80 | 0.30 | 0.29 | 0.19 |
87.9 % | 88.3 % | 92.0 % | |||||
Positive | 652 | 19 | 7 | ||||
12.1 % | 11.7 % | 8.0 % | |||||
Missing | 20,554 | 428 | 184 | ||||
79.2 % | 72.5 % | 67.9 % | |||||
TP53 | Negative | 3755 | 144 | 88 | 0.00048 | 0.21 | 0.16 |
81.6 % | 90.6 % | 86.3 % | |||||
Positive | 847 | 15 | 14 | ||||
18.4 % | 9.4 % | 13.7 % | |||||
Missing | 21,338 | 431 | 169 | ||||
82.3 % | 73.1 % | 62.4 % | |||||
Tumor size (ordinal) | <20 mm | 14,949 | 340 | 149 | 0.29 | 0.33 | 0.83 |
65.6 % | 65.6 % | 62.6 % | |||||
20–50 mm | 6953 | 162 | 82 | ||||
30.5 % | 31.3 % | 34.5 % | |||||
>50 mm | 876 | 16 | 7 | ||||
3.8 % | 3.1 % | 2.9 % | |||||
Missing | 3162 | 72 | 33 | ||||
12.2 % | 12.2 % | 12.2 % | |||||
Lymph node status | Negative | 13,144 | 320 | 125 | 0.94 | 0.91 | 0.64 |
62.0 % | 60.4 % | 57.6 % | |||||
Positive | 8070 | 210 | 92 | ||||
38.0 % | 39.6 % | 42.4 % | |||||
Missing | 4726 | 60 | 54 | ||||
18.2 % | 10.2 % | 19.9 % | |||||
Grade (ordinal) | 1 | 4916 | 132 | 38 | 0.00023 | 0.0030 | 0.38 |
22.5 % | 26.7 % | 17.4 % | |||||
2 | 10,817 | 266 | 127 | ||||
49.6 % | 53.7 % | 58.0 % | |||||
3 | 6089 | 97 | 54 | ||||
27.9 % | 19.6 % | 24.7 % | |||||
Missing | 4118 | 95 | 52 | ||||
15.9 % | 16.1 % | 19.2 % | |||||
Histological type | Ductal | 14,133 | 273 | 193 | 0.0044* | 0.0010# | 0.67# |
72.7 % | 60.0 % | 76.9 % | |||||
Lobular | 2966 | 100 | 36 | ||||
15.3 % | 22.0 % | 14.3 % | |||||
Mixed (ductal and lobular) | 455 | 26 | 4 | ||||
2.5 % | 6.0 % | 1.7 % | |||||
Tubular | 271 | 17 | 2 | ||||
1.5 % | 4.0 % | 0.7 % | |||||
Medullary | 177 | 4 | 3 | ||||
1.0 % | 0.9 % | 1.7 % | |||||
Mucinous | 213 | 9 | 3 | ||||
1.2 % | 2.1 % | 1.4 % | |||||
Papillary | 55 | 1 | 1 | ||||
0.3 % | 0.2 % | 1.8 % | |||||
Missing† | 7670 | 160 | 29 | ||||
29.6 % | 27.1 % | 10.7 % | |||||
Subtype‡ | LumA (ER+, PR+, Her2-) | 5415 | 164 | 72 | 0.00089 | 0.46 | 0.0087 |
58.9 % | 63.6 % | 65.5 % | |||||
LumB (ER+, PR-, Her2- or ER+, Her2+) | 1939 | 62 | 30 | ||||
21.1 % | 24.0 % | 27.3 % | |||||
Basal (ER-, PR-, Her2-) | 1306 | 16 | 4 | ||||
14.2 % | 6.2 % | 3.6 % | |||||
Her2-positive (ER-, PR-, Her2+) | 536 | 16 | 4 | ||||
5.8 % | 6.2 % | 3.6 % | |||||
Missing | 16,744 | 332 | 161 | ||||
64.5 % | 56.3 % | 59.4 % | |||||
AGE cat (ordinal) | 50 or younger | 6932 | 162 | 101 | 0.99 | 0.0037 | 0.0029 |
27.0 % | 27.8 % | 37.3 % | |||||
Older than 50 and not more than 70 | 16,083 | 344 | 151 | ||||
62.6 % | 59.0 % | 55.7 % | |||||
Older than 70 | 2674 | 77 | 19 | ||||
10.4 % | 13.2 % | 7.0 % | |||||
Missing | 251 | 7 | 0 | ||||
1.0 % | 1.2 % | 0.0 % | |||||
AGE | Mean | 57.1 | 57.9 | 54.3 | 0.41 | 0.028 | 0.024 |
St.dev. | 10.8 | 11.1 | 11.0 | ||||
Total | 25,940 | 590 | 271 | ||||