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Table 2 microRNAs in breast cancer cell line exosomes compared to mammary epithelial cell exosomes

From: Plasma exosome microRNAs are indicative of breast cancer

MCF7 vs. MCF10A exosome MDA-MB-231 vs. MCF10A exosome
microRNA MCF10A mean reads MCF7 mean reads Fold-change P value microRNA MCF10A mean reads MDA-MB-231 mean reads Fold-change P value
hsa-mir-1246 1236.06 10773.97 8.72 0.00E + 00 hsa-mir-21 9527.59 157280.08 16.51 1.00E-20
hsa-mir-122 18.04 751.19 41.63 0.00E + 00 hsa-let-7a-1 1470.64 30328.39 20.62 1.00E-20
hsa-mir-3662 0.45 375.59 832.59 0.00E + 00 hsa-let-7f-1 1163.88 29759.95 25.57 1.00E-20
hsa-mir-451 22.56 201.71 8.94 2.99E-10 hsa-let-7e 744.34 12747.48 17.13 1.00E-20
hsa-mir-200a 0.45 86.94 192.73 9.02E-08 hsa-mir-30e 789.45 12061.46 15.28 1.00E-20
hsa-mir-203 4.51 45.21 10.02 2.27E-03 hsa-mir-146a 76.69 11607.35 151.35 1.00E-20
hsa-mir-142 0.45 34.78 77.09 7.23E-04 hsa-let-7i 2133.78 11003.31 5.16 1.00E-20
hsa-mir-1290 0.45 34.78 77.09 7.23E-04 hsa-let-7 g 387.96 8518.10 21.96 1.00E-20
  hsa-mir-29a 360.89 6881.79 19.07 1.00E-20
  hsa-mir-29c 288.71 5744.89 19.9 1.00E-20
  1. The microRNAs with a fold-change ≥5.0 in each comparison and mapped reads ≥30 for MCF7 and ≥5000 for MDA-MB-231 are shown. The fold-change was calculated by normalizing the reads to the number of mapped reads. The P value was calculated using the likelihood ratio test. microRNAs in bold were further evaluated in this study