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Table 2 microRNAs in breast cancer cell line exosomes compared to mammary epithelial cell exosomes

From: Plasma exosome microRNAs are indicative of breast cancer

MCF7 vs. MCF10A exosome

MDA-MB-231 vs. MCF10A exosome

microRNA

MCF10A mean reads

MCF7 mean reads

Fold-change

P value

microRNA

MCF10A mean reads

MDA-MB-231 mean reads

Fold-change

P value

hsa-mir-1246

1236.06

10773.97

8.72

0.00E + 00

hsa-mir-21

9527.59

157280.08

16.51

1.00E-20

hsa-mir-122

18.04

751.19

41.63

0.00E + 00

hsa-let-7a-1

1470.64

30328.39

20.62

1.00E-20

hsa-mir-3662

0.45

375.59

832.59

0.00E + 00

hsa-let-7f-1

1163.88

29759.95

25.57

1.00E-20

hsa-mir-451

22.56

201.71

8.94

2.99E-10

hsa-let-7e

744.34

12747.48

17.13

1.00E-20

hsa-mir-200a

0.45

86.94

192.73

9.02E-08

hsa-mir-30e

789.45

12061.46

15.28

1.00E-20

hsa-mir-203

4.51

45.21

10.02

2.27E-03

hsa-mir-146a

76.69

11607.35

151.35

1.00E-20

hsa-mir-142

0.45

34.78

77.09

7.23E-04

hsa-let-7i

2133.78

11003.31

5.16

1.00E-20

hsa-mir-1290

0.45

34.78

77.09

7.23E-04

hsa-let-7 g

387.96

8518.10

21.96

1.00E-20

 

hsa-mir-29a

360.89

6881.79

19.07

1.00E-20

 

hsa-mir-29c

288.71

5744.89

19.9

1.00E-20

  1. The microRNAs with a fold-change ≥5.0 in each comparison and mapped reads ≥30 for MCF7 and ≥5000 for MDA-MB-231 are shown. The fold-change was calculated by normalizing the reads to the number of mapped reads. The P value was calculated using the likelihood ratio test. microRNAs in bold were further evaluated in this study
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Breast Cancer Research

ISSN: 1465-542X

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