Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033)

Davies, Kalatu R.; Brewster, Abenaa M.; Bedrosian, Isabelle; Parker, Patricia A.; Crosby, Melissa A.; Peterson, Susan K.; Shen, Yu; Volk, Robert J.; Cantor, Scott B.

doi:10.1186/s13058-016-0752-y

Table 5 10 and 20-year Overall and Disease-Free Survival Rate Differences by Degree of Family History of Breast Cancer

From: Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033)

Patient and Disease Characteristics			10 and 20-year absolute overall survival (OS) and disease-free survival (DFS) rate difference (%)
			No Family History				Breast Cancer IN A Second-Degree Relative				Breast Cancer in a First-Degree Relative
			No Family History				Breast Cancer IN A Second-Degree Relative				Unilateral				Bilateral
Age (years)	ER Status	Stage	10, 20yr OS Δ%		10, 20yr DFS Δ%		10, 20yr OS Δ%		10, 20yr DFS Δ%		10, 20yr OS Δ%		10, 20yr DFS Δ%		10, 20yr OS Δ%		10, 20yr DFS Δ%
40	Positive	I	0.09	0.29	1.79	2.97	0.12	0.36	2.31	3.81	0.18	0.54	3.42	5.61	0.32	0.96	6.28	10.24
40	Negative	I	0.12	0.35	2.22	3.73	0.14	0.43	2.83	4.76	0.21	0.65	4.18	6.97	0.43	1.21	7.74	12.59
40	Positive	II	0.07	0.20	1.55	2.39	0.09	0.27	2.01	3.07	0.15	0.43	2.98	4.56	0.29	0.79	5.39	8.16
40	Negative	II	0.09	0.27	1.91	2.92	0.12	0.36	2.47	3.77	0.17	0.50	3.65	5.54	0.35	0.94	6.75	10.09
40	Positive	III	0.04	0.11	1.03	1.31	0.06	0.15	1.32	1.68	0.10	0.21	1.95	2.47	0.16	0.38	3.54	4.47
40	Negative	III	0.07	0.17	1.32	1.69	0.09	0.20	1.70	2.15	0.12	0.29	2.43	3.08	0.21	0.52	4.42	5.54
50	Positive	I	0.10	0.29	1.81	2.91	0.13	0.38	2.31	3.72	0.18	0.54	3.37	5.43	0.32	0.94	6.18	9.77
50	Negative	I	0.14	0.36	2.22	3.59	0.17	0.46	2.83	4.59	0.26	0.69	4.20	6.75	0.45	1.18	7.69	12.17
50	Positive	II	0.09	0.24	1.52	2.30	0.12	0.31	1.97	2.97	0.18	0.44	2.92	4.37	0.31	0.79	5.28	7.81
50	Negative	II	0.13	0.30	1.92	2.88	0.15	0.38	2.47	3.70	0.20	0.52	3.56	5.31	0.36	0.92	6.45	9.57
50	Positive	III	0.04	0.10	0.97	1.24	0.05	0.13	1.25	1.61	0.08	0.19	1.84	2.31	0.16	0.36	3.38	4.23
50	Negative	III	0.07	0.13	1.25	1.56	0.08	0.17	1.62	2.02	0.12	0.25	2.40	2.97	0.22	0.47	4.34	5.34
60	Positive	I	0.09	0.25	1.72	2.65	0.11	0.31	2.20	3.38	0.17	0.46	3.23	4.92	0.33	0.84	6.00	9.00
60	Negative	I	0.11	0.30	2.08	3.16	0.15	0.39	2.75	4.13	0.22	0.58	4.03	6.06	0.40	1.04	7.38	10.97
60	Positive	II	0.08	0.22	1.47	2.07	0.10	0.28	1.88	2.66	0.15	0.38	2.78	3.90	0.30	0.72	5.15	7.19
60	Negative	II	0.08	0.20	1.88	2.64	0.11	0.26	2.37	3.33	0.14	0.36	3.44	4.82	0.28	0.69	6.32	8.75
60	Positive	III	0.04	0.10	0.98	1.17	0.06	0.13	1.27	1.53	0.08	0.20	1.85	2.21	0.16	0.35	3.39	3.99
60	Negative	III	0.07	0.15	1.26	1.51	0.09	0.18	1.62	1.94	0.15	0.31	2.39	2.86	0.24	0.49	4.28	5.04
					Ygy6
70	Positive	I	0.09	0.19	1.61	2.06	0.11	0.24	2.04	2.64	0.16	0.35	2.98	3.84	0.28	0.62	5.54	7.03
70	Negative	I	0.12	0.23	2.01	2.58	0.14	0.29	2.57	3.29	0.21	0.42	3.74	4.78	0.37	0.75	6.83	8.64
70	Positive	II	0.07	0.14	1.32	1.59	0.09	0.18	1.71	2.08	0.15	0.31	2.51	3.06	0.27	0.52	4.60	5.54
70	Negative	II	0.08	0.18	1.65	2.03	0.10	0.23	2.12	2.58	0.17	0.37	3.11	3.79	0.31	0.67	5.70	6.85
70	Positive	III	0.05	0.07	0.91	0.93	0.07	0.10	1.21	1.23	0.11	0.16	1.76	1.78	0.18	0.29	3.21	3.22
70	Negative	III	0.05	0.10	1.08	1.12	0.06	0.13	1.40	1.46	0.09	0.17	2.06	2.12	0.18	0.30	3.80	3.86

ER estrogen receptor, Δ%, difference %; CBC risk reduction = 95% (base-case)

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