Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033)

Davies, Kalatu R.; Brewster, Abenaa M.; Bedrosian, Isabelle; Parker, Patricia A.; Crosby, Melissa A.; Peterson, Susan K.; Shen, Yu; Volk, Robert J.; Cantor, Scott B.

doi:10.1186/s13058-016-0752-y

Table 2 Predicted Differences in Life Expectancy by Degree of Family History of Breast Cancer

From: Outcomes of contralateral prophylactic mastectomy in relation to familial history: a decision analysis (BRCR-D-16-00033)

Patient and Disease Characteristics			Life Years
			No Family History			Breast Cancer in a Second-Degree Relative			Breast Cancer in a First-Degree Relative
			No Family History			Breast Cancer in a Second-Degree Relative			Unilateral			Bilateral
Age (years)	ER Status	Stage	No CPM	CPM	Δ	No CPM	CPM	Δ	No CPM	CPM	Δ	No CPM	CPM	Δ
40	Positive	I	41.43	41.63	0.21	41.37	41.63	0.26	41.25	41.63	0.38	40.93	41.61	0.68
40	Negative	I	41.28	41.51	0.24	41.21	41.51	0.30	41.06	41.50	0.45	40.66	41.48	0.82
40	Positive	II	32.85	32.99	0.14	32.80	32.98	0.18	32.69	32.98	0.28	32.43	32.97	0.54
40	Negative	II	32.74	32.94	0.20	32.68	32.94	0.25	32.58	32.93	0.35	32.27	32.91	0.65
40	Positive	III	18.55	18.63	0.08	18.53	18.63	0.10	18.49	18.63	0.14	18.37	18.62	0.25
40	Negative	III	18.45	18.57	0.11	18.42	18.56	0.14	18.36	18.56	0.20	18.20	18.54	0.34
50	Positive	I	32.27	32.43	0.15	32.22	32.42	0.20	32.13	32.42	0.29	31.90	32.41	0.51
50	Negative	I	32.30	32.50	0.20	32.24	32.50	0.26	32.12	32.49	0.37	31.85	32.47	0.62
50	Positive	II	25.97	26.10	0.12	25.94	26.09	0.16	25.87	26.09	0.23	25.69	26.08	0.39
50	Negative	II	25.93	26.08	0.16	25.88	26.08	0.20	25.82	26.08	0.26	25.60	26.06	0.46
50	Positive	III	15.13	15.18	0.05	15.11	15.18	0.07	15.08	15.18	0.10	14.99	15.18	0.19
50	Negative	III	15.08	15.15	0.06	15.07	15.15	0.08	15.03	15.14	0.12	14.91	15.14	0.23
60	Positive	I	23.84	23.93	0.09	23.82	23.93	0.11	23.76	23.93	0.17	23.61	23.92	0.31
60	Negative	I	23.88	23.99	0.11	23.84	23.99	0.15	23.76	23.98	0.22	23.59	23.97	0.38
60	Positive	II	19.39	19.47	0.08	19.36	19.47	0.11	19.32	19.47	0.14	19.19	19.46	0.27
60	Negative	II	19.46	19.53	0.08	19.43	19.53	0.10	19.39	19.53	0.14	19.25	19.52	0.26
60	Positive	III	11.92	11.96	0.03	11.91	11.96	0.04	11.89	11.96	0.07	11.83	11.95	0.13
60	Negative	III	11.84	11.89	0.05	11.82	11.89	0.07	11.78	11.89	0.11	11.72	11.88	0.17
70	Positive	I	16.14	16.19	0.05	16.13	16.19	0.06	16.09	16.19	0.09	16.02	16.18	0.17
70	Negative	I	16.09	16.15	0.06	16.07	16.15	0.08	16.04	16.15	0.11	15.95	16.14	0.19
70	Positive	II	13.50	13.53	0.04	13.49	13.53	0.05	13.45	13.54	0.08	13.39	13.53	0.14
70	Negative	II	13.50	13.55	0.05	13.49	13.55	0.06	13.45	13.54	0.10	13.36	13.54	0.18
70	Positive	III	8.78	8.79	0.02	8.77	8.79	0.02	8.75	8.79	0.04	8.72	8.79	0.07
70	Negative	III	8.78	8.80	0.03	8.77	8.80	0.04	8.76	8.80	0.05	8.73	8.80	0.07

ER estrogen receptor, CPM contralateral prophylactic mastectomy, Δ, difference (CPM-No CPM); CBC risk reduction = 95% (base-case)

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