Table 3 Univariable Cox proportional hazard analysis of relationship between continuous MRI variables and recurrence-free survival

Baseline (before NAC)

 Largest diameter MIP/initial enhancement (90 s)

43 mm

0.238

1,009

0.994, 1.024

 Largest diameter plateau/washout enhancement (450 s)

33 mm

0.027

1,017

1.002, 1.033

 Initial enhancement (90 s) %

152 %

0.326

0.997

0.99, 1.003

 Late enhancement (450 s) %

−13 %

0.947

0.999

0.967, 1.032

During NAC

 Largest diameter MIP/initial enhancement (90s)

30 mm

0.155

1,011

0.996, 1.026

 Largest diameter plateau/washout enhancement (450 s)

17 mm

0.006

1,024

1.007, 1.041

 Initial enhancement %

135 %

0.993

1.00

0.995, 1.005

 Late enhancement %

−4 %

0.600

0.995

0.975, 1.015

After NAC

 Largest diameter MIP/initial enhancement (90s)^a

22 mm

0.140

1.01

1.00, 1.03

 Largest diameter plateau/washout enhancement (450 s)

0 mm

0.003

1.03

1.01, 1.051

 Initial enhancement %

100 %

0.057

1,005

1.00, 1.011

 Late enhancement %

9 %

0.815

0.998

0.983, 1.014

Percent change after NAC - baseline NAC %

 Largest diameter MIP/initial enhancement (90 s)^b

−40 %

0.280

1.01

0.99, 1.02

 Largest diameter plateau/washout enhancement (450 s)^c

−100 %

0.021

1,013

1.002, 1.024

Percent change after NAC - during NAC %

 Largest diameter MIP/initial enhancement (90 s) mm^b

−30 %

0.290

1.01

0.99, 1.02

 Largest diameter plateau/washout enhancement (450 s)^c

−61 %

0.066

1,008

0.999, 1.017