Fig. 9

Model for CDCP1 influences on cell-cell and substratum adhesion through a variety of mechanisms. We propose that CDCP1 participates in complexes with EGFR and Src leading to Src activation and EGFR transactivation, and that CDCP1 also participates in complexes that contain cell adhesion proteins such as cadherins and catenins. EGFR and Src have been established to reduce E-cadherin-mediated cell-cell adhesion and to induce E-cadherin internalization into cytoplasmic vesicles. Therefore, CDCP1 may abrogate cadherin adhesive function through the assembly of “anti-adhesive” complexes