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Table 1 Characteristics of all study participants and stratified by BRCA1 mutation status

From: Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific

Characteristic All
(n = 58)
BRCA1 +/+
(n = 36)
BRCA1 +/−
(n = 22)
P
Age (years), mean (range) 38 (18–62) 34.4 (18–62) 43.6 (27–62) 0.007
Ethnicity, n (%)
Other white 34 (59 %) 20 (56 %) 14 (64 %) 0.04
Ashkenazi Jewish 10 (17 %) 3 (8 %) 7 (32 %)
Hispanic 3 (5 %) 3 (8 %) 0 (0 %)
East Asian 7 (12 %) 6 (17 %) 1 (4 %)
South Asian 4 (7 %) 4 (11 %) 0 (0 %)
Parous, ever, n (%) 29 (50 %) 12 (33.3 %) 17 (77.3 %) 0.003
Breastfeeding, ever, n (%)a 23 (79 %) 10 (83 %) 13 (76 %) 1.00
Age at menarche (years), mean (SD) 12.4 (1.4) 12.2 (1.2) 12.7 (1.7) 0.20
Postmenopausal, n (%) 17 (29 %) 4 (11 %) 13 (59 %) <0.001
Current oral contraceptive use, yes, n (%) 6 (10 %) 4 (11 %) 2 (9 %) 1.00
Current smoking status, yes, n (%) 1 (2 %) 0 (0 %) 1 (5 %) 0.40
Current alcohol consumption, yes, n (%) 51 (88 %) 31 (86 %) 20 (91 %) 0.70
Prophylactic bilateral mastectomy, yes, n (%) 9 (16 %) 0 (0 %) 9 (41 %) <0.001
Prophylactic oophorectomy, yes, n (%) 14 (24 %) 1 (3 %) 13 (59 %) <0.001
Current hormone replacement therapy, yes, n (%) 10 (17 %) 3 (8 %) 7 (32 %) 0.03
BMI, kg/m2 (SD) 24.2 (5) 24.6 (5) 23.5 (4) 0.39
BRCA1 mRNA expression, mean (95 % CI) 164.3 (155, 173.5) 175.1 (163.4, 187) 146.7 (134.2, 159) 0.002
  1. aBreastfeeding among parous women. n number, SD standard deviation, BMI body mass index defined as mass in (kg) divided by height squared in (m2), CI confidence interval